A Dose-Finding Study of Pertuzumab (Perjeta) in Combination With Trastuzumab (Herceptin) in Healthy Male Participants and Women With Early Breast Cancer (EBC)

Inclusion Criteria:

* Part 1: Healthy male volunteers 18 to 45 years of age
* Part 1: Left ventricular ejection fraction (LVEF) at least 55 percent (%)
* Part 1: Body mass index (BMI) 18 to 32 kilograms per meter-squared (kg/m\^2)
* Part 1: Normal, intact skin without tattoos or lesions in the injection area
* Part 2: Females at least 18 years of age
* Part 2: Eastern Cooperative Oncology Group (ECOG) performance status of 0
* Part 2: Previously treated, non-metastatic carcinoma of the breast
* Part 2: Baseline LVEF at least 55%
* Part 2: Negative pregnancy test and use of adequate contraceptive measures among women of childbearing potential

Exclusion Criteria:

* Part 1: Positive urine test for drugs of abuse
* Part 1: History of exposure or active viral infection of Hepatitis B, hepatitis C, or human immunodeficiency virus (HIV)
* Part 1: Cardiac disease including hypertension or hypotension
* Part 1: Lower extremity edema
* Part 1: Any clinically relevant history of systemic disease
* Part 1: History of breast cancer
* Part 1: Chronic corticosteroid use
* Part 1: Receipt of IV antibiotics within 7 days prior to enrollment
* Part 2: Concurrent malignancy requiring therapy that may interfere with pharmacokinetic investigations, or history of other malignancy within 5 years prior to Screening
* Part 2: Significant cumulative exposure to anthracyclines
* Part 2: Serious cardiac disease including uncontrolled hypertension
* Part 2: Poor hematologic, renal, or hepatic function
* Part 2: Pregnant or lactating women
* Part 2: History of exposure or active viral infection of Hepatitis B, hepatitis C, or HIV
* Part 2: Chronic corticosteroid use
* Part 2: Receipt of IV antibiotics within 7 days prior to enrollment