Clinical trial · Interventional
Zero Ischemia Laparoscopic Radio Frequency/Microwave Ablation Assisted Enucleation of Renal Cell Carcinoma With T1 Stage
NCT02734329CI-TRIAL-00021997unknownN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Zero ischemia laparoscopic radio frequency ablation assisted tumor enucleation has been proved to enable tumor excision with relatively better renal function preservation comparing with conventional laparoscopic partial nephrectomy for T1a renal cell carcinoma (RCC) in a randomized clinical trial in single center. The investigators want to explore this technique to T1 RCC patients in randomized clinical trial in multiple centers.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Kidney Neoplasms | Kidney Neoplasm | ONTOLOGY_EXACT | 0.90 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| conventional laparoscopic partial nephrectomy | Procedure | — | UNRESOLVED |
| zero ischemia laparoscopic RFA/MVA assisted tumor enucleation (TE) | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Zero Ischemia group
- description
- Radiofrequency ablation(RFA) /Microwave ablation(MVA) will be performed for 1 to 4 cycles each depending on tumor size and depth. The tumor then will be laparoscopic enucleation without hilar clamping in most cases.
- interventionNames
- Procedure: zero ischemia laparoscopic RFA/MVA assisted tumor enucleation (TE)
- type
- ACTIVE_COMPARATOR
- label
- Conventional group
- description
- Renal hilum will be accurately isolated and then the artery only will be clamped during surgery.
- interventionNames
- Procedure: conventional laparoscopic partial nephrectomy
Primary outcomes (2)
- measure
- the change in glomerular filtration rate (GFR) of the affected kidney
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 15 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * patients with sporadic, unilateral, newly diagnosed T1 presumed renal cell carcinoma * patients scheduled for laparoscopic nephron sparing surgery * patients agreeable to participate in this long-term follow-up study Exclusion Criteria: * patients' aged \>80 years * patients with other renal diseases,(including kidney stone, glomerular nephritis, etc.) which might affect the renal function of the operative kidney * patients not able to tolerate the laparoscopic procedure * patients with previous renal surgery or history of any inflammatory conditions of the operative kidney * patients with the renal tumor involving urinary collecting system
References
Publications (0)
Data not yet available
No reference posted for this study.