Clinical trial · Observational
Multicentric Analysis of Predictors of N1 Upstaging After Resection of cStage-I NSCLC
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Five papers showed a lower N1 nodal upstaging with video-assisted thoracic surgery (VATS) compared to open surgery in patients with cStage-I NSCLC . This finding questions the oncologic quality of minimal invasive lung cancer surgery, especially the quality of hilar and intrapulmonary lymh node dissection. However, these retrospective studies did not include analysis of central tumor location, although central tumors have a reported higher chance of N1 upstaging . Possibly, this creates a selection bias as surgeons might select central lesions deliberately for open surgery in line with initial VATS feasibility reports
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Non Small Cell Lung Cancer | Lung Non-Small Cell Carcinoma | ALIAS | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Central/Peripheral | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- VATS
- description
- Patients operated by means of minimal invasive technique (VATS or roboticVATS)
- interventionNames
- Procedure: Central/Peripheral
- label
- Open
- description
- Patients operated by means of open thoracotomy
- interventionNames
- Procedure: Central/Peripheral
Primary outcomes (1)
- measure
- Incidence of nodal (N1 and N2) upstaging
- timeFrame
- immediate postoperative
- description
- Incidence of nodal (N1 and N2) upstaging stratified by 'central' versus 'peripheral' tumor location
Secondary outcomes (1)
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: * Patients operated in 2014 * NSCLC on final pathology * cStage-I (cT1-2a cN0 cM0 ) before start of incision for anatomical resection. * This includes: open/VATS/ Robotic Assisted Thoracoscopic Surgery (RATS) * This includes: lobectomy, bilobectomy, sleeve or pneumonectomy (not wedge) Exclusion Criteria: * Higher clinical stage than cStage-I * Former therapy for lung cancer (chemotherapy, radiotherapy, surgery) * Metastatic disease * Induction chemo- or radiotherapy * Non-anatomical resections (wedge) * Previous lymph node disease * No positron emission tomography (PET) or Missing PET report
References
Publications (0)
Data not yet available