Clinical trial · Interventional
intrathecaم Ketamine, Morphine and Both for Lower Abdominal Cancer Surgery Pain
Effects of Intrathecally Administered Ketamine, Morphine and Their Combination in Patients Undergoing Major Abdominal Cancer Surgery
NCT02726828CI-TRIAL-00025646completedPhase 2 / Phase 3ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
this study investigates the analgesic efficacy and other possible effects of ketamine, morphine, and both together when administered intrathecally for control of postoperative pain following lower abdominal cancer surgeries.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Postoperative Pain | — | UNRESOLVED | — |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| intrathecal ketamine | Drug | — | UNRESOLVED |
| intrathecal morphine | Drug | — | UNRESOLVED |
| intrathecal morphine + ketamine | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- ACTIVE_COMPARATOR
- label
- group I: morphine group
- description
- patients received 10 mg of hyperbaric bupivacaine 0.5% in 2 ml volume and 0.3 mg morphine in 1 ml volume intrathecally.
- interventionNames
- Drug: intrathecal morphine
- type
- ACTIVE_COMPARATOR
- label
- group II: ketamine group
- description
- patients received 10 mg of hyperbaric bupivacaine 0.5% in 2 ml volume and 0.1 mg/kg ketamine in 1ml volume intrathecally.
- interventionNames
- Drug: intrathecal ketamine
- type
- ACTIVE_COMPARATOR
- label
- group III: morphine + ketamine group
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 30 Years
- Maximum age
- 50 Years
Show eligibility criteria text
Inclusion Criteria: * American Society of Anesthesia (ASA) I-III patients. * aged 30-50 years. * scheduled for major abdominal cancer surgery. Exclusion Criteria: * Patients with a known allergy to the study drugs. * significant cardiac, respiratory, renal or hepatic disease. * coagulation disorders. * infection at or near the site of intrathecal injection. * drug or alcohol abuse. * BMI \> 30 kg/m2. * psychiatric illnesses that may interfere with perception and assessment of pain.
References
Publications (0)
Data not yet available
No reference posted for this study.