Clinical trial · Observational

Dual Energy CT: A New Method for Better Dose Calculation in Proton Beam Therapy

NCT02722109CI-TRIAL-00031126(DUAL)terminatedClinicalTrials.gov clinicaltrialsPublishedExplore in graph →

Why stopped (as posted): Not enough patients signed up

Summary

Brief summary (as posted)

Researchers want to compare proton stopping ratios, used for proton beam therapy planning, calculated based on single energy CT and dual energy CT images; with the intension of improve upon the proton range determination.

Conditions

Conditions (1)

Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.

Condition (as posted)	Mapped entity	Match	Confidence
Cancer	Malignant Neoplasm	ALIAS	0.90

Interventions

Interventions (1)

Intervention	Type	Mapped drug	Match
No intervention	Other	—	UNRESOLVED

Design

Arms and outcomes

Arms (0)

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Primary outcomes (1)

measure
Stopping power ratio differences
timeFrame
2 months
description
For each patient the stopping power will be calculated based on both single and dual energy CT. The treatment of the patient will not be affected in any way of this study, the patient will receive the same treatment whether or not the patient volunteers to participate in this study. And the outcome of the calculations performed in this study will have no influence for the patient. The calculations of the stopping power differences for each patient will as far as possible be done right after acquisition of the CT images, but the exact time point is not important. We will set as a deadline that the calculation for each patient is done within 2 months of acquisition of the CT images of the patient. The entire study will be finished within 2 years, and the results will be tried published in a peer-reviewed journal.

Eligibility

Eligibility (as posted)

Sex: All
Minimum age: 18 Years

Show eligibility criteria text

Inclusion Criteria:

* Cancer patients who are scheduled for a control CT scan

Exclusion Criteria:

* Under 18 years of age

References

Publications (11)

BACKGROUNDEngelsman M, Schwarz M, Dong L. Physics controversies in proton therapy. Semin Radiat Oncol. 2013 Apr;23(2):88-96. doi: 10.1016/j.semradonc.2012.11.003. PMID 23473685
BACKGROUNDKnopf AC, Lomax A. In vivo proton range verification: a review. Phys Med Biol. 2013 Aug 7;58(15):R131-60. doi: 10.1088/0031-9155/58/15/R131. Epub 2013 Jul 17. PMID 23863203
BACKGROUNDJohnson TR. Dual-energy CT: general principles. AJR Am J Roentgenol. 2012 Nov;199(5 Suppl):S3-8. doi: 10.2214/AJR.12.9116. PMID 23097165
BACKGROUNDHunemohr N, Krauss B, Tremmel C, Ackermann B, Jakel O, Greilich S. Experimental verification of ion stopping power prediction from dual energy CT data in tissue surrogates. Phys Med Biol. 2014 Jan 6;59(1):83-96. doi: 10.1088/0031-9155/59/1/83. Epub 2013 Dec 12. PMID 24334601
BACKGROUNDBourque AE, Carrier JF, Bouchard H. A stoichiometric calibration method for dual energy computed tomography. Phys Med Biol. 2014 Apr 21;59(8):2059-88. doi: 10.1088/0031-9155/59/8/2059. Epub 2014 Apr 2. PMID 24694786
BACKGROUNDHall EJ; New Collective Author. Henry S. Kaplan Distinguished Scientist Award 2003. The crooked shall be made straight; dose-response relationships for carcinogenesis. Int J Radiat Biol. 2004 May;80(5):327-37. doi: 10.1080/09553000410001695895. PMID 15223765
RESULTPaganetti H. Range uncertainties in proton therapy and the role of Monte Carlo simulations. Phys Med Biol. 2012 Jun 7;57(11):R99-117. doi: 10.1088/0031-9155/57/11/R99. Epub 2012 May 9. PMID 22571913
RESULTHudobivnik N, Schwarz F, Johnson T, Agolli L, Dedes G, Tessonnier T, Verhaegen F, Thieke C, Belka C, Sommer WH, Parodi K, Landry G. Comparison of proton therapy treatment planning for head tumors with a pencil beam algorithm on dual and single energy CT images. Med Phys. 2016 Jan;43(1):495. doi: 10.1118/1.4939106.