Clinical trial · Interventional
Laser Ablation Versus Radiofrequency Ablation for Thyroid Nodules
Prospective Randomized Comparative Study of the Effectiveness and Safety of Ultrasound-guided Laser and Radiofrequency Ablation for the Treatment of Benign Thyroid Nodules
NCT02714946CI-TRIAL-00040410LARAunknownN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is to prospectively compare percutaneous radiofrequency ablation (RFA) versus percutaneous laser ablation (LA) for the treatment of solid thyroid nodules.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Thyroid Nodule | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Percutaneous Laser Ablation | Device | — | UNRESOLVED |
| Percutaneous Radiofrequency Ablation | Device | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- LA Arm
- description
- Percutaneous Laser Ablation
- interventionNames
- Device: Percutaneous Laser Ablation
- type
- ACTIVE_COMPARATOR
- label
- RFA Arm
- description
- Percutaneous Radiofrequency Ablation
- interventionNames
- Device: Percutaneous Radiofrequency Ablation
Primary outcomes (1)
- measure
- Percentage of thyroid nodules with volume reduction at 6 and 12 months after treatment
- timeFrame
- 12 months
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 65 Years
Show eligibility criteria text
Inclusion Criteria: * Solitary thyroid nodule or dominating nodule which is well-identifiable in multinodular goiter. * Compressive and /or cosmetic symptoms caused by thyroid nodule or increase in nodule volume \>20% in 1 year even without symptoms * A nodule volume ≥ 5 ml * Solid nodule (uniformly compact or nearly completely solid, with a liquid component not exceeding 30%); * Two thyroid biopsies resulted negative for malignancy * Calcitonin levels within normal ranges Exclusion Criteria: * Hyperfunctioning lesion as evaluated biochemically and/or by 99mTc scintigraphy * Pregnancy
References
Publications (5)
- BACKGROUNDGharib H, Papini E, Paschke R, Duick DS, Valcavi R, Hegedus L, Vitti P; AACE/AME/ETA Task Force on Thyroid Nodules. American Association of Clinical Endocrinologists, Associazione Medici Endocrinologi, and European Thyroid Association medical guidelines for clinical practice for the diagnosis and management of thyroid nodules: executive summary of recommendations. J Endocrinol Invest. 2010;33(5 Suppl):51-6. PMID 20543551
- BACKGROUNDPacella CM, Bizzarri G, Guglielmi R, Anelli V, Bianchini A, Crescenzi A, Pacella S, Papini E. Thyroid tissue: US-guided percutaneous interstitial laser ablation-a feasibility study. Radiology. 2000 Dec;217(3):673-7. doi: 10.1148/radiology.217.3.r00dc09673. PMID 11110927
- BACKGROUNDAhmed M, Brace CL, Lee FT Jr, Goldberg SN. Principles of and advances in percutaneous ablation. Radiology. 2011 Feb;258(2):351-69. doi: 10.1148/radiol.10081634. PMID 21273519
- BACKGROUNDPapini E, Guglielmi R, Bizzarri G, Graziano F, Bianchini A, Brufani C, Pacella S, Valle D, Pacella CM. Treatment of benign cold thyroid nodules: a randomized clinical trial of percutaneous laser ablation versus levothyroxine therapy or follow-up. Thyroid. 2007 Mar;17(3):229-35. doi: 10.1089/thy.2006.0204. PMID 17381356
- BACKGROUNDCesareo R, Pasqualini V, Simeoni C, Sacchi M, Saralli E, Campagna G, Cianni R. Prospective study of effectiveness of ultrasound-guided radiofrequency ablation versus control group in patients affected by benign thyroid nodules. J Clin Endocrinol Metab. 2015 Feb;100(2):460-6. doi: 10.1210/jc.2014-2186. Epub 2014 Nov 11. PMID 25387256