Clinical trial · Interventional
MR-HIFU for Recurrent Gynaecological Cancer
Magnetic Resonance Guided High Intensity Focused Ultrasound (MRgHIFU): A Feasibility Study for Treating Recurrent Gynaecological Malignancies
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The primary objective of this pilot study is to determine whether or not it is feasible to use MRgHIFU to treat symptomatic (pain, bleeding) recurrent pelvic malignancy with an acceptable safety profile when conventional treatment options are not available. The ultimate goal is to be able not only to offer a viable method of symptom palliation in patients with recurrent pelvic tumours and improve their quality of life; but also to control tumour growth and extend life in a group of relatively young patients with isolated local recurrence.
Conditions
Conditions (6)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cervical Cancer | Malignant Cervical Neoplasm | CURATED_EXACT | 0.92 |
| Endometrial Cancer | Malignant Endometrial Neoplasm | CURATED_BROADER | 0.80 |
| Ovarian Cancer | Malignant Ovarian Neoplasm | CURATED_EXACT | 0.92 |
| Uterine Cancer | Malignant Uterine Neoplasm | ALIAS | 0.90 |
| Vaginal Cancer | Malignant Vaginal Neoplasm | CURATED_EXACT | 0.92 |
| Vulvar Cancer | Malignant Vulvar Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Magnetic Resonance Image-guided High Intensity Focused Ultrasound (MR-HIFU) | Device | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- NO_INTERVENTION
- label
- Feasibility of MR-HIFU for painful gynaecological metastases
- description
- Investigating whether it would be possible to use the MRgHIFU system to treat recurrent gynaecological cancers.
- type
- EXPERIMENTAL
- label
- Treatment using MR-HIFU of painful gynaecological metastases
- description
- Testing whether MRgHIFU could be an effective treatment for the symptoms of recurrent gynaecological cancers (pain and bleeding)
- interventionNames
- Device: Magnetic Resonance Image-guided High Intensity Focused Ultrasound (MR-HIFU)
Primary outcomes (1)
- measure
- Changes in pain, measured using a patient diary
- timeFrame
- 7 days post-treatment, follow up at 90 days
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Patients with recurrent pelvic gynaecological malignancy (cervix and endometrial cancer). * Recurrent lesion is painful (NRS\>4) and not suitable for alternative treatments * Intended target volume accessible for MRgHIFU treatment * Intended target volume visible on noncontrast MR imaging * Distance between target and skin ≥1cm Exclusion Criteria: * MRI contraindicated (e.g. by incompatible metal implants or claustrophobia) * Pregnancy * Sedation contraindicated * MRI contrast agent contraindicated * Scar, internal or external fixation device along the beam path or at the target
References
Publications (1)
- DERIVEDImseeh G, Giles SL, Taylor A, Brown MRD, Rivens I, Gordon-Williams R, Ter Haar G, deSouza NM. Feasibility of palliating recurrent gynecological tumors with MRGHIFU: comparison of symptom, quality-of-life, and imaging response in intra and extra-pelvic disease. Int J Hyperthermia. 2021;38(1):623-632. doi: 10.1080/02656736.2021.1904154. PMID 33882792