Clinical trial · Interventional
Stereotactic Radiosurgery for Soft Tissue Sarcoma
NCT02706171CI-TRIAL-00075038withdrawnN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study is evaluating treatment with CyberKnife for soft tissue sarcomas.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Soft Tissue Sarcoma | Soft Tissue Sarcoma | ONTOLOGY_EXACT | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| CyberKnife | Radiation | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- EXPERIMENTAL
- label
- A: pre-operative
- description
- Radiation- CyberKnife: 35-40 Gy over 5 fractions Surgery: Surgical resection of sarcoma
- interventionNames
- Radiation: CyberKnife
- type
- EXPERIMENTAL
- label
- B: Post-operative
- description
- Radiation- CyberKnife: 40 Gy over 5 fractions
- interventionNames
- Radiation: CyberKnife
- type
- EXPERIMENTAL
- label
- C: Non-resectable
- description
- Radiation- CyberKnife: 50 Gy over 5 fractions
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * All cohorts: * Age \> 18 * Patients of child-bearing age must agree to contraception until radiosurgery has been completed. * Note that patients with metastatic disease are eligible for protocol * Cohort 1: Soft tissue sarcoma (of any histology subtype) in patients that are -planned to have pre-operative radiation followed by surgical resection * Anatomical site to include upper extremity (including shoulder) and lower extremity (including hip) * Patient performance status and co-morbid conditions to allow for surgical resection * Cohort 2: soft tissue sarcoma (of any histologic subtype) post-resection with no further plans for additional surgery. * Patients must have high risk feature requiring post-operative radiation which can include Large tumor (\> 5 cm), High grade, Previous unplanned, non, oncologic surgery, Close margins * Anatomical site to include upper extremity (including shoulder) and lower extremity (including hip) * Cohort 3: soft tissue sarcoma (of any histologic subtype) that is not amenable to surgical resection for any reason * Anatomical site to include upper extremity (including shoulder) and lower extremity (including hip and pelvis) * Patients cannot have planned surgical resection * Note that retroperitoneal sarcomas are not eligible Exclusion Criteria: -Tumors that do not fit criteria for any of the above cohorts
References
Publications (1)
- DERIVEDKubicek GJ, Kim TW, Gutowski CJ, Kaden M, Eastwick G, Khrizman P, Xu Q, Lackman R. Preoperative Stereotactic Body Radiation Therapy for Soft-Tissue Sarcoma: Results of Phase 2 Study. Adv Radiat Oncol. 2021 Nov 20;7(2):100855. doi: 10.1016/j.adro.2021.100855. eCollection 2022 Mar-Apr. PMID 35387414