Clinical trial · Observational
EVIS - Ex-vivo Assessment of T-lymphocyte Homing in Primary Pancreatic Cancer
A Feasibility Study Assessing the Ability of an Ex-vivo Assay to Measure AMD3100's Ability to Overcome Tumour Immune-privilege and Bring T-lymphocytes Into Contact With Neoplastic Targets.
NCT02695966CI-TRIAL-00039512EVIScompletedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This is a single-centre, prospective, non-randomised research study. The research team will investigate the feasibility of assessing primary human pancreatic tissue for changes to T lymphocyte function and localisation in the presence and absence of AMD3100.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Pancreatic Cancer | Malignant Pancreatic Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Whipples Surgery | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (2)
- measure
- Cancer cell distribution
- timeFrame
- 12 months
- description
- Tumour tissue analysis
- measure
- T lymphocyte changes
- timeFrame
- 12 months
- description
- DNA, RNA and protein tumour tissue analysis
Secondary outcomes (1)
- measure
- T lymphocyte localisation
- timeFrame
- 12 months
- description
- Tumour tissue analysis using study drug and other agents
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Patients with primary pancreatic adenocarcinoma who are undergoing pancreaticoduodenectomy (Whipple's) resection. * Patients who are over 18 years of age at the time of signing the informed consent form and who are physically and mentally capable of consenting. * Willing and able to comply with study procedures. Exclusion Criteria: • Any condition or abnormalities that in the judgment of the investigator/surgeon/ histopathologist would place the patient at undue risk.
References
Publications (0)
Data not yet available
No reference posted for this study.