Clinical trial · Observational
Chile Biliary Longitudinal Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Background: The gallbladder is a small organ below the liver. Gallbladder cancer is a leading cause of cancer death among women in Chile. Chile also has among the highest rates of gallbladder cancer and death in the world. Researchers in a high-risk region of Chile want to find out more about this type of cancer. They especially want to know how inflammation affects the way it develops. Objective: To better understand the causes of gallbladder diseases and factors that may be associated with them. Eligibility: Women ages 50 74 with gallbladder cancer who are covered by the Chilean national health system. Other people over age 21 with gallbladder disease. Healthy adults over age 21. Design: Participants may be screened with an ultrasound. They may be asked questions about their health. Participants will have an ultrasound of the abdomen. This can be done at the study clinic or in the hospital or at home. The ultrasound uses sound waves to take pictures of the gallbladder. Participants will have a physical exam. Participants will have their mouths looked at for tooth loss, dentures, and gum redness. Participants will give a blood sample or saliva sample. Participants will be asked for access to their medical history. They may be asked to allow researchers to keep any samples taken during gallbladder surgery. Participants will answer questions about their medical history. This will include illnesses, surgeries, medicine use, and family history. It will also include diet and lifestyle habits, such as places where they have lived and worked. Some participants will have 3 follow-up visits over 6 years. ...
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Gallbladder Cancer | Malignant Gallbladder Neoplasm | CURATED_EXACT | 0.92 |
| Nutritional and Metabolic Diseases | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (1)
- label
- Women with gallstones
- description
- Women aged 50-74 with gallstones
Primary outcomes (1)
- measure
- Cancer/precancer
- timeFrame
- during course of the study
- description
- Our major exposures of interest are patterns, levels, and changes in inflammatory markers and ultrasound characteristics, with Gallbladder Dysplasia and Cancer as the primary outcome of interest.
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 50 Years
- Maximum age
- 74 Years
Show eligibility criteria text
* INCLUSION CRITERIA: General Population Cohort: * Female * Age 50 years to 74 years * No previous cholecystectomy * Covered by National Health Insurance * Resident of Araucania (or Maule) * Able to answer questionnaire (due to language/communication issues or mental incapacity) Other control (general population or cholecystectomy): * No previous cholecystectomy * Covered by National Health Insurance * Resident of Araucania (or Maule) * Able to answer questionnaire (due to language/communication issues or mental incapacity) Gallbladder Cancer Group: * Diagnosis within study time period * Primary site of cancer is the gallbladder with histological or radiological confirmation * Covered by National Health Insurance * Resident of Araucania (or Maule) * Able to answer questionnaire (due to language/communication issues or mental incapacity) EXCLUSION CRITERIA: General Population Cohort: * Male * Age less than 50 years or greater than 74 years * History of previous cholecystectomy * Not covered by National Health Insurance * Not a Resident of Araucania (or Maule) * Unable to answer questionnaire (due to language/communication issues or mental incapacity) Other control (general population or cholecystectomy): * History of previous cholecystectomy * Not covered by National Health Insurance * Not a Resident of Araucania (or Maule) * Unable to answer questionnaire (due to language/communication issues or mental incapacity) Gallbladder Cancer Group: * Diagnosis not within study time period * Primary site of cancer is NOT the gallbladder with histological or radiological confirmation * Not covered by National Health Insurance * Not a Resident of Araucania (or Maule) * Unable to answer questionnaire (due to language/communication issues or mental incapacity)
References
Publications (0)
Data not yet available