Clinical trial · Interventional
Healing of the Esophageal Mucosa After RFA of Barrett's Esophagus
Healing of the Esophageal Mucosa After Radiofrequency Ablation of Barrett's Esophagus
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Radiofrequency ablation (RFA) is a mainstay of treatment for patients who have Barrett's esophagus (BE) with dysplasia. For unclear reasons, Barrett's esophagus recurs after successful RFA treatment in approximately 1/3 of patients. The aim of this study is to characterize the healing process of the esophageal mucosa, histologically and at the molecular level, after RFA for non-dysplastic and dysplastic Barrett's esophagus.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Barrett Esophagus | — | UNRESOLVED | — |
Interventions
Interventions (5)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Baseline surveillance endoscopy | Procedure | — | UNRESOLVED |
| Follow up endoscopy 1 | Procedure | — | UNRESOLVED |
| Follow up endoscopy 2 | Procedure | — | UNRESOLVED |
| Follow up endoscopy 3 | Procedure | — | UNRESOLVED |
| Radiofrequency ablation | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Barrett's Esophagus Treatment
- description
- All participants are in the treatment arm. Patients with Barrett's esophagus will undergo baseline surveillance endoscopy, be treated with radiofrequency ablation, and undergo follow up endoscopy 1, follow up endoscopy 2, and follow up endoscopy 3.
- interventionNames
- Procedure: Baseline surveillance endoscopy
- Procedure: Radiofrequency ablation
- Procedure: Follow up endoscopy 1
- Procedure: Follow up endoscopy 2
- Procedure: Follow up endoscopy 3
Primary outcomes (1)
- measure
- Change in the Percent of Mucosa Healed by Neosquamous Epithelium
- timeFrame
- 1 week, 2 weeks, 4 weeks
- description
- % of the esophageal mucosa healed by Neosquamous epithelium at 1 week, 2 weeks, and 4 weeks after RFA
Secondary outcomes (2)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: \- Barrett's esophagus Exclusion Criteria: * inability to provide informed consent * esophageal varices * treatment with warfarin * coagulopathy that precludes safe biopsy of the esophagus (including platelet count \<100,000/mm3, INR (international normalized ratio) \>1.5) * allergy to fluorescein sodium * comorbidity that precludes safe participation in the study * pregnancy or breastfeeding status
References
Publications (0)
Data not yet available