A Study of Cediranib and Olaparib at Disease Worsening in Ovarian Cancer

Inclusion Criteria:

* Age \>= 18 years.
* Performance status \<= 2.
* Histologically confirmed ovarian cancer, high grade serous or high grade endometrioid histology subtype.
* Radiographically documented disease progression within 28 days of registration and evaluable.
* Radiological progression on any PARP inhibitor therapy (example: olaparib):

  * a cohort of platinum sensitive recurrence and response for at least 6 months on PARP inhibitor treatment
  * a cohort of platinum resistance with disease progression within 6 months after the last dose of a platinum based chemotherapy
* Patients who discontinue PARP therapy will be eligible after a break in therapy or intervening therapy.
* Patients must have adequate bone marrow, renal and hepatic function per local laboratory reference range.
* Ongoing prior toxicities related to previous treatments must be recovered to \<= grade 2 at the time of registration.
* Left ventricular ejection fraction (LVEF) \>= 50% by echocardiograms or multigated acquisition (MUGA) scan within 28 days of registration.
* Acceptable urine dipstick/urine analysis for proteinuria.
* Patients are willing to undergo tumour biopsy pre-treatment if a biopsy at the time of progression on olaparib is not available.
* Life expectancy of greater than 3 months.
* Ability to understand and the willingness to sign a written informed consent document.
* Patient's willingness and ability to comply with scheduled visits, treatment plans, laboratory tests, and other study procedures.
* Patients of child bearing potential and their partners who are sexually active must agree to the use of 2 highly effective forms of contraception throughout their participation during the study treatment and for 3 months after last dose of study treatment(s).

Exclusion Criteria:

* Patients with current bowel obstruction.
* Patients with known brain metastases.
* Unacceptable mean corrected QT (QTc) in screening electrocardiograms within 7 days of registration or history of familial long QT syndrome.
* Uncontrolled intercurrent illness including, but not limited to hypertension, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.
* A New York Heart Association classification of III or IV.
* History of allergic reactions attributed to compounds of similar chemical or biologic composition to olaparib or cediranib.
* Patients unable to swallow orally administered medication and patients with gastrointestinal disorders likely to interfere with absorption of the study medication.
* Patients with myelodysplastic syndrome/acute myeloid leukaemia.
* Immuno-compromised patients, e.g., patients who are known to be serologically positive for human immunodeficiency virus (HIV), patients with known active hepatitis (i.e., hepatitis B or C) due to risk of transmitting the infection through blood or other body fluids.
* Patients who require maximal doses of calcium channel blockers to stabilize blood pressure.
* Patients with significant hemorrhage or haemoptysis.
* Patients who have had recent (within 2 weeks of registration, or until any wound has completely healed) major thoracic or abdominal surgery prior to study start, or a surgical incision that is not fully healed.
* History of stroke or transient ischemic attack within six months.
* Patients that are receiving and cannot stop the following prohibited medications prior to Cycle 1, Day 1.
* Other severe acute or chronic medical or psychiatric condition or laboratory abnormality that may increase the risk associated with study participation or study drug administration, or may interfere with the interpretation of study results, and in the judgment of the investigator would make the subject inappropriate for entry into this study.