Clinical trial · Interventional
Head and Neck Squamous Cell Carcinoma (HNSCC)PET-CT Pilot Study
A Pilot Study of 18F-FDG PET-CT Kinetic Analysis in Head and Neck Squamous Cell Carcinoma (HNSCC)
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is to see how useful the information provided from Positron Emission Tomography (PET) scans can be in the actual planning and delivery of radiation treatment to patients who have head and neck cancers. Patients participating in this study, will have (in addition to their routine tests) a PET scan before and during their radiation treatment. Following the intervention, patients will be followed as per standard practice.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Head and Neck Squamous Cell Carcinoma | Head and Neck Squamous Cell Carcinoma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| 18-F FDG | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- HNSCC Patients receiving RT
- interventionNames
- Drug: 18-F FDG
Primary outcomes (1)
- measure
- Measure rate constant of 18F-FDG uptake in tumour and normal tissue with dynamic PET scanning before radiotherapy.
- timeFrame
- ~ 2 years
Secondary outcomes (1)
- measure
- Measure rate constant of 18F-FDG uptake in tumour and inflammatory tissue with dynamic PET scanning during radiotherapy .
- timeFrame
- ~ 2 years
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Non-nasopharynx head and neck mucosal squamous cell carcinoma * Radiologically evident gross disease * Radiotherapy alone for curative intent * Age equal to or more than 18 years old * To be eligible for the second study PET-CT scan: FDG avid tumour (or minimum SUV of 2.5) on the first study PET-CT scan Exclusion Criteria: * Nasopharynx cancer * H\&N SCC skin * Distant metastases (already known or if found on baseline CT-thorax) * Prior malignancy within the last 5 years (exclude non-H\&N SCC, BCC skin) * Prior chemotherapy within the last 5 years or concurrent chemotherapy/EGFR inhibitors * Prior head and neck radiotherapy * Inability to lie supine for study duration * Pregnancy * Inability to provide informed consent
References
Publications (0)
Data not yet available