Cisplatin Combined With S-1 or Paclitaxel as First-line Treatment for Metastatic Esophageal Squamous Cell Carcinoma

Inclusion Criteria:

* Histologically proven primary thoracic esophageal squamous cell carcinoma
* Not suitable for surgery or radio or chemical therapy
* Presence of at least one index lesion measurable by CT scan or MRI radiation therapy ended at least 4 weeks, but part of the radiation does not as a measurable lesions
* 18\~70 years
* PS:0-1
* Life expectancy of ≥ 3 months
* WBC≥3.5×109/L,ANC≥1.5×109/L, PLT≥100×109/L, Hb≥100g/L
* TB ≤ 1.5UNL, ALT/AST ≤ 2.5×UNL
* Scr≥60 mL/min
* Normal electrocardiogram (ecg)
* Can normal oral drugs
* Signed written informed consent

Exclusion Criteria:

* Breast-feeding or pregnant women, no effective contraception if risk of conception exists
* Chronic diarrhea, enteritis, intestine obstruction which are not under control
* Esophageal obstruction cannot eat liquid completely, esophagus have deep ulcer perforation or hematemesis; Esophageal cancer common complications such as anastomotic leakage, serious lung complications, etc.
* A second primary tumor (except skin basal cell carcinoma)
* The original serious heart disease, including: higher risk of congestive heart failure, unable to control arrhythmia, unstable angina, myocardial infarction, severe valvular heart disease, and resistant hypertension
* With uncontrol nerve, mental illness or mental disorders, compliance is poor, can't cooperate with accounts and response to treatment; Primary brain tumors or - CNS metastases illness did not get a control, has obvious cranial hypertension or nerve mental symptoms
* With bleeding tendency
* Has inherited bleeding evidence of physical or blood coagulation disorder
* With clear chemotherapy drug allergy
* Other researchers believe that patients should not participate in this testing