Prospective Study to Evaluate Safety of Deb-TACE With 100µ Beads in Patients With Non Resectable HCC

Inclusion Criteria:

1. Patients with a diagnosis of HCC according to European Association for the Study of the Liver (EASL) and American Association for the Study of Liver Diseases (AASLD) criteria and staged by BCLC criteria
2. Indication for receiving transarterial chemoembolization DEB-TACE with 100 µ microspheres according to usual clinical practice.
3. Able and willing to participate and give their written informed consent.
4. Both genders and ≥ 18 years old.
5. Eastern Cooperative Oncology Group (ECOG) 0
6. Preserved hepatic function (Child-Pugh ≤ B7).
7. No evidence of tumoral invasion in portal vein or main biliary ducts.
8. Able to go through image diagnostic techniques such as CT or MRI.
9. Preserved cardiac and renal function.
10. No concomitant active infections that require antibiotic treatment.
11. Measurable disease according to mRECIST criteria.
12. Life expectancy over 6 months.

Exclusion Criteria:

1. ECOG ≥ 1
2. Child-Pugh ≥B8.
3. Presence of ascitis or encephalopathy
4. Extrahepatic tumoral disease.
5. Tumoral vascular invasion
6. Serum bilirubin\>3 mg/dl.
7. Cr Clearance ≤ 60 ml/min
8. If any of the following is contraindicated:

   1. Administration of doxorubicin
   2. Iodated contrasts
   3. CT or MRI procedures
   4. Transarterial embolization procedures
   5. White blood cells (WBC) \< 2000 /mm3
   6. Neutrophil count \< 1500 /mm3
   7. Ejection fraction \< 50 %
   8. Platelet count \< 5 x 104/mm3, international normalized ratio (INR) \> 2,0)
   9. Transaminases (AST and/or ALT) \> 5x upper limit of normal or \>250 u/l
   10. Known hepatofugal portal vein flow
   11. A-V intrahepatic macroscopic fistula
9. Pregnant or breast feeding women.
10. Tumor burden involving more than 50% of the liver.
11. Active bacterial or fungal infection.
12. Other concomitant tumors.
13. Any other condition that according to investigator criteria, contraindicates DEB-TACE.
14. Patients not willing to participate and/or give their written informed consent.