Clinical trial · Interventional
Comparison of Colon Adenoma Detection Rate Using Two Distal Colonoscope Attachments
NCT02665741CI-TRIAL-00045603completedN/AResults postedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The goal of this study is to compare two FDA approved distal colonoscope attachment devices, in order to identify which device can increase adenoma detection rate the most without increasing procedure time or risk.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colon Adenomas | — | UNRESOLVED | — |
| Colon Cancer Screening | — | UNRESOLVED | — |
| Colon Polyps | — | UNRESOLVED | — |
| Water Exchange Colonoscopy | — | UNRESOLVED | — |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Control | Device | — | UNRESOLVED |
| Medivators Endocuff | Device | — | UNRESOLVED |
| Olympus transparent cap | Device | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- OTHER
- label
- Control
- description
- Standard colonoscopy - no distal colonoscope attachment will be used in this arm
- interventionNames
- Device: Control
- type
- EXPERIMENTAL
- label
- Olympus transparent cap
- description
- The Olympus transparent cap will be attached to the distal end of colonoscope prior to starting the procedure
- interventionNames
- Device: Olympus transparent cap
- type
- EXPERIMENTAL
- label
- Medivators Endocuff
- description
- The Medivators Endocuff will be attached to the distal end of colonoscope prior to starting the procedure
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 50 Years
Show eligibility criteria text
Inclusion Criteria: * At least 50 years old * Presenting for a screening or surveillance colonoscopy at UC Davis Endoscopy Suites Exclusion Criteria: * Age less than 50 years * Prior history of colon cancer * Patients with inflammatory bowel disease * Patients suspected to have colon cancer based on non invasive tests such as stool tests for hemoglobin or DNA, or imaging finding suggestive of colon cancer (CT or barium enema). * Patients undergoing colonoscopy for evaluation of symptoms such as abdominal pain, rectal bleeding, diarrhea, constipation, etc, or patient with iron deficiency anemia suspected to be due to ongoing bleeding inside the colon * Patients with family history of colon cancer in 1st degree relative below the age of 60 * Patients with family history of hereditary polyposis syndromes such as Lynch syndrome, familial adenomatous polyposis etc, which are associated with an increased risk of colon cancer * Patients unable to consent * Pregnant patients * Incarcerated patients * Non-English speakers
References
Publications (4)
- BACKGROUNDBrenner H, Hoffmeister M, Arndt V, Stegmaier C, Altenhofen L, Haug U. Protection from right- and left-sided colorectal neoplasms after colonoscopy: population-based study. J Natl Cancer Inst. 2010 Jan 20;102(2):89-95. doi: 10.1093/jnci/djp436. Epub 2009 Dec 30. PMID 20042716
- BACKGROUNDPioche M, Matsumoto M, Takamaru H, Sakamoto T, Nakajima T, Matsuda T, Abe S, Kakugawa Y, Otake Y, Saito Y. Endocuff-assisted colonoscopy increases polyp detection rate: a simulated randomized study involving an anatomic colorectal model and 32 international endoscopists. Surg Endosc. 2016 Jan;30(1):288-95. doi: 10.1007/s00464-015-4208-8. Epub 2015 Apr 11. PMID 25861907
- BACKGROUNDWestwood DA, Alexakis N, Connor SJ. Transparent cap-assisted colonoscopy versus standard adult colonoscopy: a systematic review and meta-analysis. Dis Colon Rectum. 2012 Feb;55(2):218-25. doi: 10.1097/DCR.0b013e31823461ef. PMID 22228167
- BACKGROUNDHarada Y, Hirasawa D, Fujita N, Noda Y, Kobayashi G, Ishida K, Yonechi M, Ito K, Suzuki T, Sugawara T, Horaguchi J, Takasawa O, Obana T, Oohira T, Onochi K, Kanno Y, Kuroha M, Iwai W. Impact of a transparent hood on the performance of total colonoscopy: a randomized controlled trial. Gastrointest Endosc. 2009 Mar;69(3 Pt 2):637-44. doi: 10.1016/j.gie.2008.08.029. PMID 19251004