Clinical trial · Interventional
The Clinical Physics Research of Image Guided Adaptive Radiation Therapy for Esophagus Cancer
NCT02653521CI-TRIAL-00029861unknownN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is to evaluate the benefit of adaptive radiation therapy (adaptive radiation therapy, ART) for esophageal cancer, using dose tracking technique with online images and deformable registration.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Esophageal Cancer | Malignant Esophageal Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Dose adaptation | Radiation | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- adaptive radiation therapy (ART)
- description
- 40 patients treated with ART, using dose adaptation method to match the change of PTV and movement of OARs and achieve an optimal dose distribution using online CBCT images.
- interventionNames
- Radiation: Dose adaptation
- type
- NO_INTERVENTION
- label
- the control group
- description
- 40 patients treated with original plan for full treatment course.
Primary outcomes (1)
- measure
- Toxicity of treatment
- timeFrame
- One year
- description
- Evaluating the treatment toxicity weekly during treatment course and at the time of one year after treatment according to the NCI CTCAE 4.0 (The National Cancer Institute Common Terminology Criteria for Adverse Events,NCI-CTCAE, Version 4.0).
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 70 Years
Show eligibility criteria text
Inclusion Criteria: * Diagnosed with locally advanced esophageal cancer * ECOG(Eastern Cooperative Oncology Group, ECOG) physical status score：0-2 * Charlson complications index score≤4 * First second forced expiratory volume ≥1 liter * Patients and their families agreed and signed the informed consent Exclusion Criteria: * Previous treatment with other malignant tumor * Had anti-tumor treatment, including (chemotherapy, radiotherapy, surgery) * Any taboo disease or condition of radiotherapy and chemotherapy * With malignant pleural effusion and pericardial effusion * Participated to other clinical test within 30 days before this experiment * With uncontrolled seizures or loss of mental self-control * Drug takers, chronic alcoholism, and HIV/AIDS patients * Has a history of severe allergic or specific physique * Researchers think that is unfavorable to the test
References
Publications (2)
- BACKGROUNDHawkins MA, Brooks C, Hansen VN, Aitken A, Tait DM. Cone beam computed tomography-derived adaptive radiotherapy for radical treatment of esophageal cancer. Int J Radiat Oncol Biol Phys. 2010 Jun 1;77(2):378-83. doi: 10.1016/j.ijrobp.2009.05.045. Epub 2009 Sep 21. PMID 19775828
- BACKGROUNDSriram P, Syamkumar SA, Kumar JS, Prabakar S, Dhanabalan R, Vivekanandan N. Adaptive volumetric modulated arc treatment planning for esophageal cancers using cone beam computed tomography. Phys Med. 2012 Oct;28(4):327-32. doi: 10.1016/j.ejmp.2011.10.006. Epub 2011 Nov 10. PMID 22079402