Cavity Shaving in Breast Conserving Surgery for Breast Cancer Patients

This randomized controlled trial is to evaluate the impact of additional cavity shaving (CS) on pathological cavity margin (CM) status in breast cancer patients. Patients receiving standard breast-conserving surgery (BCS) will be randomized to intra-operative CM assessment versus intra-operative CS followed by CM assessment. The primary objective of this study is to assess the impact of CS on intra-operative CM status, intra-operative re-excision rate, post-operative CM status and re-excision rate, cosmetic outcomes, and on intraoperative time and medical costs.

Sex

Female

Minimum age

18 Years

Maximum age

65 Years

Inclusion Criteria:

* Female
* At least 18 years of age and no more than 65 years of age
* Able to understand and willing to sign an informed consent document
* Willing and planning to undergo the breast-conserving surgery
* ECOG≤ 2

Exclusion Criteria:

* Inflammatory breast cancer
* Preference for mastectomy instead of breast-conserving surgery
* Necessity to undergo oncoplastic breast surgery
* Prior surgical treatment, including ultrasound-guided vacuum-assisted biopsy and excision biopsy.
* Prior systemic therapy for this diagnosis, including neoadjuvant chemotherapy, neoadjuvant endocrine therapy.
* History of prior breast/axillary radiation therapy
* Known metastatic disease
* Diagnosed as bilateral breast cancer or DCIS
* History of other malignancy ≤ 5 years previous
* Preoperation evaluation indicates tumor size\>5cm
* Preoperation evaluation indicates multicenter or multifocal breast cancer(including suspicious calcification on mammography)
* Undergoing other clinical trials
* With sever liver disfunction(Child-Pugh C)
* With sever cardiac insufficiency
* With sever renal disfunction
* Pregnancy

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