Clinical trial · Interventional
Stem Cell Therapy Combined With NeuroRegen Scaffold™ in Patients With Erectile Dysfunction After Rectal Cancer Surgery
Bone Marrow Mononuclear Cells or Human Umbilical Cord-derived Mesenchymal Stem Cells Combined With NeuroRegen Scaffold™ Transplantation for the Improvement of Erectile Function in Men After Rectal Cancer Surgery
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Erectile dysfunction (ED) is one of the commonest complications in men after rectal cancer treatment. The purpose of this study is to assess the safety and efficacy of autologous bone marrow mononuclear cells (BMMCs) or allogeneic human umbilical cord-derived mesenchymal stem cells (HUC-MSCs) combined with NeuroRegen scaffold transplantation in men with erectile dysfunction after rectal cancer treatment.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Erectile Dysfunction | — | UNRESOLVED | — |
| Rectal Cancer | Malignant Rectal Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (4)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Laparoscopic surgery | Procedure | — | UNRESOLVED |
| NeuroRegen scaffold/BMMCs transplantation | Biological | — | UNRESOLVED |
| NeuroRegen scaffold/HUC-MSCs transplantation | Biological | — | UNRESOLVED |
| NeuroRegen scaffold transplantation | Device | — | UNRESOLVED |
Design
Arms and outcomes
Arms (4)
- type
- SHAM_COMPARATOR
- label
- Laparoscopic surgery
- description
- Patients receive no interventions after rectal cancer treatment.
- interventionNames
- Procedure: Laparoscopic surgery
- type
- EXPERIMENTAL
- label
- NeuroRegen scaffold transplantation
- description
- Patients receive NeuroRegen scaffold transplantation after rectal cancer treatment.
- interventionNames
- Device: NeuroRegen scaffold transplantation
- type
- EXPERIMENTAL
- label
- NeuroRegen scaffold/BMMCs transplantation
- description
Eligibility
Eligibility (as posted)
- Sex
- Male
- Minimum age
- 20 Years
- Maximum age
- 65 Years
Show eligibility criteria text
Inclusion Criteria: 1. Diagnosed with local rectal cancer, which is within 12cm from anus. 2. Male, 20-65 years old. 3. IIEF-5 score\> 21. 4. No obvious abnormal in external genitalia, testis, epididymis and spermatic cord. 5. Have a consistent partner who is willing to engage in sexual activity more than twice per month during the study. 6. Signed informed consent. 7. Recently take no drugs affecting sexual function (such as androgen replacement drugs, PDE5i and Chinese patent medicine, etc.). Exclusion Criteria: 1. Suffering hypertension or diabetes. 2. In the investigators judgment, with clinical significance of penis abnormalities, or has received penile prosthesis implantation surgery. 3. Patient's partner is trying to conceive during the trial period. 4. Exposure to any investigational drug or procedure within 1 month prior to study entry or enrolled in a concurrent study that may confound results of this study. 5. Geographically inaccessible for follow-up visits required by protocol or want to other treatment.
References
Publications (0)
Data not yet available