Clinical trial · Observational
Heterogeneity of Metastatic Neuroendocrine Tumors as Determined With 18F-dihydroxyphenylalanine-PET /CT, a Retrospective Analysis
NCT02646644CI-TRIAL-00076784HET-NETcompletedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
In an individual cancer patient extensive genetic and phenotypic variation exists between and within tumor lesions. Tumour load in NET patients can be measured with fluorine-18-L-dihydroxyphenylalaninepositron emission tomography (18F-DOPA-PET) scan. This aim of the study is to investigate heterogeneity between tumor lesions within patients with intestinal NET by determining the differences in tracer uptake measured on a 18F- DOPA-PET scan retrospectively.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Neuroendocrine Tumors | Neuroendocrine Tumor | ONTOLOGY_EXACT | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Metastasized intestinal NET | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Metastasized intestinal NET
- description
- We will select the 18F- DOPA-PET scans conducted in the Universtiy Medical Center of Groningen (UMCG) of adult patients with a metastasized intestinal NET between February 2014 until November 2015. Only patients of whose clinical data are available within the UMCG are included.
- interventionNames
- Other: Metastasized intestinal NET
Primary outcomes (1)
- measure
- tracer uptake in tumor lesions within patients with intestinal NET
- timeFrame
- at the day of scan
- description
- The difference in tracer uptake of tumor lesions within patients with intestinal NET measured on a 18F- DOPA-PET scan.
Secondary outcomes (1)
- measure
- tracer uptake in tumor lesions within patients with intestinal NET adjusted for uptake of background organ
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * age ≥18 years * diagnosis of intestinal NET diagnosed by a dedicated NET specialist * more than one positive lesion on the 18F-DOPA-PET scan. * available CT-scan within 6 months before or after the 18F-DOPA-PET-scan. Exclusion Criteria: * no clinical data available at the UMCG, besides the results of the DOPA PET scan.
References
Publications (0)
Data not yet available
No reference posted for this study.