Clinical trial · Observational
Comparison of Circulating Tumor DNA and Tumor Tissue DNA by Targeted Sequencing in Non-Small Cell Lung Cancer
A Prospective Study of Circulating Tumor DNA Detection by Targeted Sequencing in Surgical Non-Small Cell Lung Cancer Patients
NCT02645318CI-TRIAL-00020401completedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Conduct a prospective study to compare gene detection by ctDNA with tumor tissue DNA via targeted DNA sequencing in surgical NSCLC patients.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Carcinoma, Non-Small-Cell Lung | Lung Non-Small Cell Carcinoma | ALIAS | 0.90 |
Interventions
Interventions (0)
Data not yet available
No intervention recorded.
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- Whether ctDNA can detect genomic alterations in peripheral blood that are consistent with those in matched tumor sample
- timeFrame
- 2-3 months
Secondary outcomes (4)
- measure
- Concordance of tDNA and plasma ctDNA gene detection in early stage non-small cell lung cancer
- timeFrame
- 2-3months
- measure
- Correlation of ctDNA concentration with clinical features
- timeFrame
- 2-3months
- measure
- Comparison of positive predictive value between ctDNA and tumor markers
- timeFrame
- 2-3months
- measure
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Patient who is confirmed primary lung cancer by frozen pathologic histology * Both the fresh tissue tumor and plasma samples are collected for analysis Exclusion Criteria: * Patients who received any treatment prior to resection * Patients who have a history of malignancy * Paraffin embedded section confirmed small cell lung cancer or unclassified carcinoma * Tumor specimens where insufficient DNA
References
Publications (0)
Data not yet available
No reference posted for this study.