Clinical trial · Interventional
Uncut Roux-en-Y Gastrojejunostomy for Early Gastric Cancer Patients
The Effect of Uncut Roux-en-Y Gastrojejunostomy on Quality of Life After Laparoscopic Distal Gastrectomy for Early Gastric Cancer Patients
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The current commonly used for distal gastri cancer in gastrointestinal anastomosis is Roux-en-Y. However, the complications after Roux-en-Y reach an incidence of over 30% which involve nausea, vomiting, and abdominal distension. The underlying mechanism might be the result of interruption of intestine peristalsis. In 2013, Kim reported total laparoscopic uncut Roux-en-Y anastomosis could reduce Roux stasis syndrome incidence by keeping the continuity of jejunum. In September 2014, we carried out this operation in 30 cases in our centre. Our previous results showed that this operation had a low postoperative complication and short hospitalization time, indicating uncut Roux-en-Y anastomosis might be a safe procedure. However, some limitations are noticed. The report from South Korea is a retrospective study and the evaluation of QOL is certain subjective. Here, we aimed to perform the first randomized controlled clinical study on uncut Roux-en-Y anastomosis to improve QOL of patients after laparoscopic distal gastrectomy.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Gastric Cancer | Malignant Gastric Neoplasm | CURATED_BROADER | 0.80 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Conventional Roux-en-Y Gastrojejunostomy | Procedure | — | UNRESOLVED |
| Uncut Roux-en-Y Gastrojejunostomy | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- OTHER
- label
- Conventional Roux-en-Y anastomosis
- description
- Conventional Roux-en-Y Gastrojejunostomy will be used after laparoscopic distal gastrectomy for early gastric cancer.
- interventionNames
- Procedure: Conventional Roux-en-Y Gastrojejunostomy
- type
- EXPERIMENTAL
- label
- Uncut Roux-en-Y anastomosis
- description
- Uncut Roux-en-Y Gastrojejunostomy will be used after laparoscopic distal gastrectomy for early gastric cancer.
- interventionNames
- Procedure: Uncut Roux-en-Y Gastrojejunostomy
Primary outcomes (1)
- measure
- Quality of life
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 70 Years
Show eligibility criteria text
Inclusion Criteria: * Endoscopy and biopsy confirmed gastric antrum or angle (from the cardia more than 4cm) of gastric cancer * tumor stage: I * There is no experience with chemotherapy, no distant metastasis * Have their own ability to answer the questionnaire * There is no mental illness * Age between 18-70 years old * Agreed to participate in the experiment and signed informed consent Exclusion Criteria: * pregnant or nursing patients * The combined more serious cardiovascular disease, liver and kidney dysfunction (glutamic-pyruvic transaminase/glutamic oxalacetic transaminase more than three times the upper limit of normal, serum creatinine more than 50% higher than the upper limit of normal), abnormal blood clotting function (mean prothrombin time, activated partial thromboplastin time higher than normal values above the upper limit of 50%), neuropsychiatric disorders * Patients with active infection * Have other malignant tumor * Some reason withdraw subjects, can not enrolled in the study again
References
Publications (2)
- DERIVEDCai Z, Mu M, Ma Q, Liu C, Jiang Z, Liu B, Ji G, Zhang B. Uncut Roux-en-Y reconstruction after distal gastrectomy for gastric cancer. Cochrane Database Syst Rev. 2024 Feb 29;2(2):CD015014. doi: 10.1002/14651858.CD015014.pub2. PMID 38421211
- DERIVEDXu H, Yang L, Zhang DC, Li Z, Li QY, Wang LJ, Li FY, Wang WZ, Xia YW, Xu ZK. To cut or not to cut? A prospective randomized controlled trial on short-term outcomes of the uncut Roux-en-Y reconstruction for gastric cancer. Surg Endosc. 2023 Aug;37(8):6172-6184. doi: 10.1007/s00464-023-10067-0. Epub 2023 May 9. PMID 37160808