Absorption, Metabolism, Excretion and Pharmacokinetics of a Single Dose [14C]AZD2014 Followed by a Multiple Dose Phase

Inclusion Criteria:

* Provision of signed, written \& dated informed consent prior to any study specific procedures.
* Male or female patients aged at least 18 years.
* Have a body mass index (BMI) ≥18 kg/m2 and ≤35 kg/m2 \& weigh at least 50 kg.
* Histological or cytological confirmation of a solid malignant tumour that is refractory or resistant to standard therapies or for which no suitable effective standard therapies exist. SqNSCLC patients are excluded from the 50mg BD AZD2014 in combination with paclitaxel cohort.
* For patients intending to enter combination therapy with fulvestrant or paclitaxel, this should be deemed as an appropriate treatment option by Investigator.
* Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 2 with no deterioration over previous 2 weeks \& minimum life expectancy of 12 weeks.
* At least one lesion (measurable and/or non-measurable but evaluable) that can be accurately assessed at baseline by computerised tomography (CT) magnetic resonance imaging (MRI) or plain X-ray \& is suitable for repeated assessment
* Able \& willing to stay in hospital for approximately 9 days
* Females should be using adequate contraceptive measures, should not be breast feeding \& must have negative pregnancy test prior to start of dosing if of childbearing potential or must have evidence of non-childbearing potential
* Male patients should be surgically sterile or willing to use barrier contraception ie, condoms and spermicide \&refrain from donating sperm from start of dosing until 16 weeks after discontinuing of study treatment.
* Regular bowel movements (ie, on average production of at least 1 stool per day)

Exclusion Criteria:

* Involvement in planning and/or conduct of the study
* Previous enrolment in present study
* Another study with an investigational product in last 28 days
* Chemotherapy, biological therapy, radiation therapy, androgens, thalidomide, immunotherapy, other anticancer agents \& any investigational agents within 21 days of starting treatment (not including palliative radiotherapy at focal sites), or corticosteroids within 14 days
* Major surgery within 4 weeks, or minor surgery within 14 days
* Exposure to strong and moderate inhibitors or inducers of cytochrome P450 (CYP) 3A4/5, P-glycoprotein (Pgp) (multidrug resistance gene \[MDR1\]), and breast cancer resistance protein (BCRP), if taken within stated washout periods
* Exposure to specific substrates of the drug organic anion-transporting polypeptide (OATP)1B1, OATP1B3, organic anion transporting polypeptide (OCT)1 and OCT2 within appropriate washout period
* Any haemopoietic growth factors (eg, filgrastim \[granulocyte colony-stimulating factor; G-CSF\], sargramostim \[granulocyte-macrophage colony-stimulating factor; GM-CSF\]) within 14 days prior to receiving study treatment
* Previous treatment with AZD2014 or AZD8055
* Patients who have received fulvestrant within 3 months
* With exception of alopecia, any unresolved toxicities chemotherapy/radiotherapy should be no greater than CTCAE grade 1
* Participated in another absorption, distribution, metabolism and excretion study within 1 year
* Spinal cord compression and/or brain metastases unless asymptomatic or treated \& stable off steroids for at least 4 weeks
* Severe or uncontrolled systemic diseases (eg, severe hepatic impairment, interstitial lung disease \[bilateral, diffuse, parenchymal lung disease\]), or current unstable or uncompensated respiratory or cardiac conditions, or uncontrolled hypertension, active bleeding diatheses or active infection including hepatitis B, hepatitis C and human immunodeficiency virus (HIV).
* Recent history of drug abuse or alcohol abuse
* Patients who have undergone any of the following procedures or experienced conditions currently or in preceding 12 months:

  * Coronary artery bypass graft
  * Angioplasty
  * Vascular stent
  * Myocardial infarction
  * Angina pectoris
  * Congestive heart failure New York Heart Association Grade 2
  * Ventricular arrhythmias requiring continuous therapy
  * Uncontrolled supraventricular arrhythmias including atrial fibrillation
  * Haemorrhagic or thrombotic stroke, including transient ischaemic attacks or other central nervous system bleeding
* Abnormal echocardiogram at baseline (left ventricular ejection fraction \[LVEF\] \<55% and shortening fraction \[SF\] \<15%)
* Torsades de Pointes either currently or within 12 months
* Mean resting QTcF ≥470 ms
* Medications known to prolong QT interval, or that increase the risk of QTc prolongation or arrhythmic events (such as heart failure, hypokalaemia, congenital long QT syndrome, family history of either long QT syndrome), or unexplained sudden death under 40 years of age
* Laboratory values as listed below:

  * Absolute neutrophil count \<1.5x109/L
  * Platelet count \<100x109/L
  * Haemoglobin \<90 g/L
  * Alanine aminotransferase (ALT) or aspartate aminotransferase (AST) \>2.5 times upper limit of normal (ULN) if no demonstrable liver metastases or \>5xULN in the presence of liver metastases
  * Total bilirubin \>1.5xULN if no demonstrable liver metastases or \>3xULN in the presence of liver metastases
  * Serum creatinine \>1.5xULN concurrent with creatinine clearance \<50 mL/min (measured or calculated by Cockcroft and Gault equation), confirmation of creatinine clearance is only required when creatinine is \>1.5xULN
  * Clinically relevant and treatment resistant abnormalities in potassium, sodium, calcium (corrected for plasma albumin) or magnesium
* Pre-existing renal disease including glomerulonephritis, nephritic syndrome, Fanconi Syndrome or renal tubular acidosis
* Abnormal fasting glucose \>126 mg/dL (\>7 mmol/L)
* Patients with diabetes Type 1 or uncontrolled Type 2 (glycosylated haemoglobin \[HbA1c\] \>8% \[64 mmol/mol\] assessed locally)
* Current refractory nausea and vomiting, chronic gastrointestinal disease or inability to swallow the formulated product or previous significant bowel resection that would preclude adequate absorption
* History of hypersensitivity to active or inactive excipients of AZD2014 or drugs with a similar chemical structure or class to AZD2014
* Judgment that patient is unsuitable to participate in study and unlikely to comply with study procedures, restrictions \& requirements