Clinical trial · Interventional
Effects of Ilaprazole on Ulcer Healing Rate and Prevention of Gastrointestinal Bleeding in the Patients Undergone ESD.
Effects of Ilaprazole 20mg on Ulcer Healing Rate and Prevention of Gastrointestinal Bleeding in the Patients Undergone Endoscopic Submucosal Dissection(ESD) for Gastric Adenoma or Early Gastric Cancer.
NCT02638584CI-TRIAL-00046333completedPhase 4ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study compared Ulcer healing rate of Ilaprazole 20mg or Rabeprazole 20mg in the patients undergone Endoscopic Submucosal Dissection for Gastric Adenoma or Early Gastric Cancer and investigated Prevention of gastrointestinal bleeding.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Gastric Cancer | Malignant Gastric Neoplasm | CURATED_BROADER | 0.80 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Ilaprazole | Drug | — | UNRESOLVED |
| Rabeprazole | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Ilaprazole
- description
- Ilaprazole tab 10mg, 2 tablets once daily for 8 weeks.
- interventionNames
- Drug: Ilaprazole
- type
- ACTIVE_COMPARATOR
- label
- Rabeprazole
- description
- Rabeprazole tab 20mg, 1 tablet once daily for 8 weeks.
- interventionNames
- Drug: Rabeprazole
Primary outcomes (1)
- measure
- The Ulcer healing rate after endoscopic submucosal dissection
- timeFrame
- participants will be followed at 8 weeks
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 19 Years
- Maximum age
- 85 Years
Show eligibility criteria text
Inclusion Criteria: * 19 year old ≤ Male or female \< 85 year old * Subject who underwent Endoscopic Submucosal Dissection for Gastric Adenoma or Early Gastric Cancer * Subject who agrees to participate and spontaneously sign the Informed consent form(ICF). Exclusion Criteria: * Known hypersensitivity to any component of ilaprazole * Subjects who are taking contraindicated medications(ex. atazanavir) for experimental and concomitant drug. * Subjects with abnormal levels in the laboratory tests * Total Bilirubin, Creatinine\> 1.5 times upper limit of normal * Alanine transaminase(ALT), Aspartate transaminase(AST), Alkaline phosphatase, Blood urea nitrogen(BUN)\> 2 times upper limit of normal * Subjects diagnosed with other cancer within 5 years other than stomach cancer. * Subjects with a history of Zollinger-Ellison syndrome, Barrett's esophagus, primary esophageal motility abnormality, esophageal strictures, pancreatitis, malabsorption, severe cardiovascular or pulmonary disease * Subjects with a history of major surgery that can affect gastric acid secretion. * Subjects should continue taking the following medicine during the study period : anticholinergics, promoting motility agents, prostaglandin analogs, sucralfate, aspirin, steroid, NSAIDs drug * Subjects with uncontrolled organ failure (liver dysfunction, renal dysfunction) * Pregnant and/or lactating women * Subjects participating in a clinical trial before another trial within 30 days * Inconsistency judged subject by researcher
References
Publications (1)
- DERIVEDBang CS, Shin WG, Seo SI, Choi MH, Jang HJ, Park SW, Kae SH, Yang YJ, Shin SP, Baik GH, Kim HY. Effect of ilaprazole on the healing of endoscopic submucosal dissection-induced gastric ulcer: randomized-controlled, multicenter study. Surg Endosc. 2019 May;33(5):1376-1385. doi: 10.1007/s00464-018-6412-9. Epub 2018 Aug 30. PMID 30167954