Pilot Study of Non-Viral, RNA-Redirected Autologous T Cells in Patients With Refractory or Relapsed Hodgkin Lymphoma

Inclusion Criteria:

* Male or female subjects with HL with no available curative treatment options (such as autologous SCT) who have a limited prognosis (several months to \< 2 year survival) with currently available therapies will be enrolled.

  * HL with biopsy-proven relapse or refractory disease who are unresponsive to or intolerant of at least one line of standard salvage therapy;
  * Patients must have evaluable disease by radiologic imaging (FDG PET-CT or FDG PET-MRI) within 42 day of enrollment; evaluable includes both assessable and/or measurable disease
* Age 18 to 24 years. Patients ages 22-24 will only be enrolled if they are currently being treated at CHOP or another pediatric facility/oncologist.
* Expected survival \> 12 weeks at time of screening
* Adequate organ function defined as:
* Renal function defined as:

  * Creatinine clearance or radioisotope GFR \> 60 mL/min/1.73 m2 OR
  * Serum creatinine: \< 1.7mg/dL (male subjects) or \< 1.4mg/dL (female subjects)
* ALT \< 5 times the ULN for age
* Total Bilirubin \< 2.0 mg/dl
* Must have a minimum level of pulmonary reserve defined as ≤ Grade 1 dyspnea and pulse oxygenation \> 94% on room air
* Patients with relapsed disease after prior allogeneic SCT (myeloablative or non-myeloablative) will be eligible if they meet all other inclusion criteria and
* Have no active GVHD and require no immunosuppression
* Are more than 6 months from transplant 6) Karnofsky performance status ≥ 50 at screening
* Left Ventricular Shortening Fraction (LVSF) \> 28% confirmed by echocardiogram, or Left Ventricular Ejection Fraction (LVEF) \> 45% confirmed by echocardiogram or MUGA
* Signed written informed consent must be obtained prior to any study procedures
* Successful T cell test expansion (to be performed as part of inclusion criteria until 3 subjects meet all enrollment criteria)

Exclusion Criteria:

* Pregnant or lactating women. The safety of this therapy on unborn children is not known. Female study participants of reproductive potential must have a negative serum pregnancy test at enrollment. A urine pregnancy test will be performed within 48 hours before the RNA CART19 infusion.
* Uncontrolled active infection.
* Active hepatitis B or hepatitis C infection.
* Any uncontrolled active medical disorder that would preclude participation as outlined.
* HIV infection.
* Patients with known active CNS involvement by malignancy. Patients with prior CNS disease that has been effectively treated will be eligible providing treatment was \>4 weeks before enrollment
* Patients in complete remission with no evidence by radiologic imaging of disease.
* History of allergy to murine proteins
* History of allergy or hypersensitivity to study product excipients (human serum albumin, DMSO, and Dextran 40).
* Anti-CD20 monoclonal antibody therapy within the last 3 months, or absence of circulating B cells
* Unstable angina and/or myocardial infarction within 6 months prior to screening.