Clinical trial · Interventional
Efficacy and Safety of Posterior Retroperitoneoscopic Adrenalectomy: A Comparative Study
Posterior Retroperitoneoscopic Approach Versus Transperitoneal Laparoscopic Approach in Management of Adrenal Tumors: A Randomized Comparative Study
NCT02618694CI-TRIAL-00026245PostLapAdrnlcompletedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This randomized comparative study assesses the safety and efficacy of the posterior retroperitoneoscopic adrenalectomy in comparison to the standard, anterior transperitoneal approach and suppose that this new technique is a safe and effective alternative to the standard approach.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Adrenal Disease | — | UNRESOLVED | — |
| Adrenal Mass | — | UNRESOLVED | — |
| Cushing Syndrome | — | UNRESOLVED | — |
| Pheochromocytoma | Adrenal Gland Pheochromocytoma | ALIAS | 0.90 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Posterior retroperitoneoscopic adrenalectomy | Procedure | — | UNRESOLVED |
| Transperitoneal laparoscopic adrenalectomy | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Group 1
- description
- patient had posterior retroperitoneoscopic adrenalectomy
- interventionNames
- Procedure: Posterior retroperitoneoscopic adrenalectomy
- type
- ACTIVE_COMPARATOR
- label
- Group 2
- description
- patient had Transperitoneal laparoscopic adrenalectomy
- interventionNames
- Procedure: Transperitoneal laparoscopic adrenalectomy
Primary outcomes (4)
- measure
- Mean operative time
- timeFrame
- 1 year
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: patients have one or more of the following; * Functioning adrenal adenoma, * Nonfunctioning adenoma \< 7 cm by pelvi-abdominal CT, * Secondary metastatic adrenal mass suitable for laparoscopic adrenalectomy, * Adrenal hyperplasia indicated for laparoscopic adrenalectomy. Exclusion Criteria: * Patients with cardiovascular disease (as angina, acute myocardial infection, congestive heart failure); history of stroke, transient myocardial attacks, coronary angioplasty or coronary artery bypass graft surgery, or any other contraindication for laparoscopy e.g. COPD, * Pregnant females, * Locally advanced malignant disease, * Evidence of regional lymph node involvement, * Vascular malignant invasion, * Malignant uncontrolled hypertension with pheochromocytoma, * Need for other simultaneous surgical intervention at the same session e.g. cholecystectomy.
References
Publications (18)
- BACKGROUNDConstantinides VA, Christakis I, Touska P, Palazzo FF. Systematic review and meta-analysis of retroperitoneoscopic versus laparoscopic adrenalectomy. Br J Surg. 2012 Dec;99(12):1639-48. doi: 10.1002/bjs.8921. Epub 2012 Sep 28. PMID 23023976
- BACKGROUNDDickson PV, Alex GC, Grubbs EG, Ayala-Ramirez M, Jimenez C, Evans DB, Lee JE, Perrier ND. Posterior retroperitoneoscopic adrenalectomy is a safe and effective alternative to transabdominal laparoscopic adrenalectomy for pheochromocytoma. Surgery. 2011 Sep;150(3):452-8. doi: 10.1016/j.surg.2011.07.004. PMID 21878230
- BACKGROUNDDickson PV, Jimenez C, Chisholm GB, Kennamer DL, Ng C, Grubbs EG, Evans DB, Lee JE, Perrier ND. Posterior retroperitoneoscopic adrenalectomy: a contemporary American experience. J Am Coll Surg. 2011 Apr;212(4):659-65; discussion 665-7. doi: 10.1016/j.jamcollsurg.2010.12.023. PMID 21463807
- BACKGROUNDDoublet, J. D., Janetscek, G., Joyce, A., Mandressi, A., Rassweiller, J., & Tolley, D. (2002). Guidelines in laparoscopy. European Association of Urology.
- BACKGROUNDEichel, L., & Clayman, R. V. (2012). Fundamentals of laparoscopic and robotic urologic surgery. In A. J. Wein, S. R. Kavoussi, A. C. Novick, A. W. Partin, & C. A. Peters, Campell and Walsh Urology (pp. 204-253). Philadelphia: Saunders.
- BACKGROUNDEkstein P, Szold A, Sagie B, Werbin N, Klausner JM, Weinbroum AA. Laparoscopic surgery may be associated with severe pain and high analgesia requirements in the immediate postoperative period. Ann Surg. 2006 Jan;243(1):41-6. doi: 10.1097/01.sla.0000193806.81428.6f. PMID 16371735
- BACKGROUNDGeorge, A. K., & Kavoussi, L. R. (2010). Laparoscopic Adrenalectomy. In S. D. Graham, T. E. Keane, S. D. Graham, & T. E. Keane (Eds.), Glenn's Urologic Surgery (pp. 859-866). Phiadelphia: Lippincott Williams and Wilkins.
- BACKGROUNDLinos, D. (2005). Left anterior laparoscopic adrenalectomy. In D. Linos, & J. A. van Heerden, Adrenal Glnads (pp. 320-324). Berlin: Springers.