Clinical trial · Interventional
Effects of Resistance and Endurance Training in Pediatric Cancer Patients During Intensive Treatment Phase
Effects of Combined Resistance and Endurance Training in Pediatric Cancer Patients During Intensive Treatment Phase
NCT02612025CI-TRIAL-00037410MUCKIcompletedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is to determine whether combined endurance and resistance training can improve muscle strength in children and adolescents with cancer during the intensive treatment phase.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Pediatric Oncology | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Exercise Training | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Exercise group
- description
- Exercise training during intensive medical treatment
- interventionNames
- Behavioral: Exercise Training
- type
- NO_INTERVENTION
- label
- Control group
- description
- Usual Care
Primary outcomes (1)
- measure
- Muscle strength: lower limb
- timeFrame
- Six weeks (pre-post intervention)
- description
- Lower limb muscle strength measured by the load (kg) sustained in one repetition maximum test
Secondary outcomes (7)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 4 Years
- Maximum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Malignant Tumor * Medical Treatment in the Center for Pediatrics, Hematology, Oncology and Hemostaseology Mainz (Germany) * \> 3 years * Signed Informed Consent Exclusion Criteria: * Functional and/or cognitive limitations which limit performance during training * Orthopedic condition which hinders to adequately participate in exercise training * Heart failure (NYHA III-IV) * Partial or global respiratory failure * Symptomatic coronary disease * Serious therapy-refractory hypertonia * Sustainable thrombocytopenia \<10.000/µl, f. ex. therapy-refractory autoimmune thrombocytopenia * Hereditary or acquired thrombocytopenia or coagulation disturbance * Uncontrolled cerebral spasm * CNS metastases * Medical or psychological condition which does in the doctors opinion not allow participation in sport activity
References
Publications (2)
- DERIVEDWinker M, Stossel S, Neu MA, Lehmann N, El Malki K, Paret C, Joisten N, Bloch W, Zimmer P, Faber J. Exercise reduces systemic immune inflammation index (SII) in childhood cancer patients. Support Care Cancer. 2022 Apr;30(4):2905-2908. doi: 10.1007/s00520-021-06719-3. Epub 2021 Dec 3. PMID 34860287
- DERIVEDStossel S, Neu MA, Wingerter A, Bloch W, Zimmer P, Paret C, Malki KE, Baumann FT, Russo A, Henninger N, Lehmann N, Otto H, Faber J. Benefits of Exercise Training for Children and Adolescents Undergoing Cancer Treatment: Results From the Randomized Controlled MUCKI Trial. Front Pediatr. 2020 Jun 5;8:243. doi: 10.3389/fped.2020.00243. eCollection 2020. PMID 32582585