Clinical trial · Interventional
Effect of Over-the-counter Toothpastes on Chemotherapy-induced Oral Mucositis
Comparison of the Healing of Chemotherapy-Induced Oral Mucositis Using Oral Defense Toothpaste Versus Crest Toothpaste and Magic Mouth Rinse
NCT02606994CI-TRIAL-00036975TPvsMterminatedPhase 2ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): Lack of enrollment
Summary
Brief summary (as posted)
The purpose of this study is to determine whether Oral Defense Toothpaste causes accelerated healing of chemotherapy-induced oral mucositis.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Mucositis | — | UNRESOLVED | — |
| Neoplasms | Neoplasm | ONTOLOGY_EXACT | 0.90 |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Crest Toothpaste | Drug | — | UNRESOLVED |
| Magic Mouth Rinse | Drug | — | UNRESOLVED |
| Oral Defense Toothpaste | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Oral Defense Toothpaste
- description
- The experimental group will brush with Oral Defense Toothpaste three times per day during the study
- interventionNames
- Drug: Oral Defense Toothpaste
- type
- PLACEBO_COMPARATOR
- label
- Crest Toothpaste/Magic Mouth Rinse
- description
- The placebo group will brush with Crest Toothpaste three times per day during the study. Participants in the placebo comparator group who require additional management of their oral mucositis pain will be provided Magic Mouth Rinse.
- interventionNames
- Drug: Crest Toothpaste
- Drug: Magic Mouth Rinse
Primary outcomes (1)
- measure
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Patients over the age of 18 receiving chemotherapy * Mucositis lesions not exceeding grade 2 Exclusion Criteria: * Patients receiving high load chemotherapy * Patients receiving radiation therapy * Patients receiving oral antivirals, oral antifungals or oral antibacterials * Patients experiencing oral candidiasis
References
Publications (0)
Data not yet available
No reference posted for this study.