Estimate the Efficacy of HD6610 Granule for Oxaliplatin-induced Peripheral Neuropathy

Inclusion Criteria:

1. All cases have been diagnosed with colorectal cancer by pathology;
2. Patients who received no chemotherapy before should receive oxaliplatin-based chemotherapy(FOLFOX4,FOLFOX6,XELOX) ;
3. Patients of 18-70 years old have no serious heart,liver,kidney and hematopoietic disfunction,life expectancy of over 3 months and KPS more than 60;
4. Patients with no positive sign in neurological examination,and no drug allergy history or diabetes;
5. Volunteered to participate and signed informed consent,patients can not receive radiotherapy,acupuncture and moxibustion or other treatment during the experiment.

Exclusion Criteria:

1. Not accordant with the inclusion criteria;
2. Patients who have used herbal within 4 weeks before registration;
3. Patients who have serious heart,liver,kidney and hematopoietic disfunction;
4. Patients of central nervous system disease;
5. Patients of cervical spondylopathy,lumbar disc protrusion,diabetes and uremia which can potentially cause peripheral neuropathy;
6. Nerve compression caused by tumor metastasis or peripheral neuropathy caused by electrolyte disturbances,diabetes,alcohol disease and other disorder;
7. Long-time using of thiazide diuretic and foxglove;
8. Patients of poisoning,infection and radiotherapy which induced peripheral neuropathy or receiving medicine which can cause peripheral neuropathy;
9. Patients who can hardly take Chinese Medicine with severe diarrhea,vomiting or intestinal obstruction ;
10. Uncontrolled psychosis;
11. Women of pregnancy ,preparing pregnant, or lactation;
12. Alcohol and drug abuse;
13. Allergic constitution or allergy to experiment drugs.