Clinical trial · Interventional
Extent of Breast Cancer and the Role of Pre-Operative Sonography and MRI
Sonography Compared With MRI in Pre-Operative Evaluation of Patients With Breast Cancer to Determine Extent of Breast Disease
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This clinical trial studies mammography and targeted ultrasound with or without whole-breast ultrasound or contrast-enhanced magnetic resonance imaging (MRI) in finding out the extent of disease before surgery in patients with newly diagnosed breast cancer. New diagnostic imaging procedures, such as whole-breast ultrasound or contrast-enhanced MRI, may help find out how far breast cancer has spread. It is not yet known whether mammography and targeted ultrasound are more effective with or without whole-breast ultrasound or contrast-enhanced MRI in finding out how far breast cancer has spread.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Ductal Breast Carcinoma In Situ | Breast Ductal Carcinoma In Situ | ALIAS | 0.90 |
| Stage IA Breast Cancer | Malignant Breast Neoplasm | CURATED_BROADER | 0.78 |
| Stage IB Breast Cancer | Malignant Breast Neoplasm | CURATED_BROADER | 0.78 |
| Stage II Breast Cancer | Malignant Breast Neoplasm | CURATED_BROADER | 0.78 |
Interventions
Interventions (5)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Contrast-enhanced Magnetic Resonance Imaging | Procedure | — | UNRESOLVED |
| Gadolinium | Other | — | UNRESOLVED |
| Mammography | Procedure | — | UNRESOLVED |
| Therapeutic Conventional Surgery | Procedure | — | UNRESOLVED |
| Ultrasonography | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- ACTIVE_COMPARATOR
- label
- Group 1 (standard of care)
- description
- Patients undergo standard of care diagnostic imaging comprising bilateral mammography and targeted breast ultrasound.
- interventionNames
- Procedure: Mammography
- Procedure: Therapeutic Conventional Surgery
- Procedure: Ultrasonography
- type
- EXPERIMENTAL
- label
- Group 2 (bilateral whole-breast ultrasound)
- description
- Patients undergo standard of care diagnostic imaging as in Group 1. Patients also undergo bilateral whole-breast ultrasound.
- interventionNames
- Procedure: Mammography
- Procedure: Therapeutic Conventional Surgery
- Procedure: Ultrasonography
- type
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Competent to provide informed consent * Pathologically proven invasive breast cancer or ductal carcinoma in situ (DCIS) originally identified clinically or mammographically and diagnosed by percutaneous core biopsy * Eligible for breast conserving surgery followed by radiation therapy Exclusion Criteria: * Women with surgical excisional biopsy that diagnosed the breast cancer * Women with clinical or mammographic findings where breast conserving surgery is not an option * Women that clinically or mammographically have breast cancers that are fixed to skin * Women receiving neoadjuvant chemotherapy prior to surgery * Women having contraindications to contrast-enhanced (CE)-MRI examination (e.g., claustrophobia and allergy to gadolinium)
References
Publications (0)
Data not yet available