Clinical trial · Observational
Metabolic Changes in Blood Samples From Patients With Acute Myeloid Leukemia
A Study of the Metabolic Changes in Leukemia Cells Following Treatment in AML Patients
NCT02581917CI-TRIAL-00061564completedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This research trial studies metabolic changes in blood samples from patients with acute myeloid leukemia. Studying samples of blood from patients with acute myeloid leukemia in the laboratory may help doctors learn more about cancer and the development of drug resistance.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Recurrent Adult Acute Myeloid Leukemia | Adult Acute Myeloid Leukemia | CURATED_BROADER | 0.78 |
| Untreated Adult Acute Myeloid Leukemia | Adult Acute Myeloid Leukemia | CURATED_BROADER | 0.78 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Cytology Specimen Collection Procedure | Other | — | UNRESOLVED |
| Laboratory Biomarker Analysis | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Ancillary-Correlative (metabolic changes)
- description
- Patients undergo collection of PBMC samples for analysis via cell isolation, glycolytic flux and oxygen consumption assays, viability assays, and western blot at baseline, 24, 48, and 72 hours after starting chemotherapy.
- interventionNames
- Other: Cytology Specimen Collection Procedure
- Other: Laboratory Biomarker Analysis
Primary outcomes (11)
- measure
- Glycolytic flux rate
- timeFrame
- Up to 72 hours after starting chemotherapy
- description
- Results will be analyzed using descriptive statistics. Comparison between groups will be done using t-tests or ANOVA procedures. Other inferential statistical analysis will be conducted as appropriate.
- measure
- Level of fatty acid synthase by western blot
- timeFrame
- Up to 72 hours after starting chemotherapy
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Patients scheduled to initiate chemotherapy for either an initial diagnosis of AML or relapsed AML * Starting the initial induction phase of therapy * Exposure to hydroxyurea is acceptable but must be noted at the time of sample collection * Ability to understand and the willingness to sign an institutional review board (IRB)-approved informed consent Exclusion Criteria: * Received at least one dose of chemotherapy during the current cycle (excluding hydroxyurea).
References
Publications (0)
Data not yet available
No reference posted for this study.