Clinical trial · Interventional
Effect of Propofol-Dexmedetomidine on Cerebral Oxygenation and Metabolism During Brain Tumor Resection
Effect of Propofol-Dexmedetomidine Total Intravenous Anaesthesia on Cerebral Oxygenation and Metabolism During Brain Tumor Resection Compared to Sevoflurane Anaesthesia
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Despite theoretical benefits of intravenous agents, volatile agents remain popular. In a study comparing desflurane, isoflurane, and sevoflurane in a porcine model of intracranial hypertension, at equipotent doses and normocapnia, cerebral blood flow (CBF) and intra-cranial pressure (ICP) were least with sevoflurane. Propofol is the most commonly used intravenous anesthetic. It has many theoretical advantages by reducing cerebral blood volume (CBV) and ICP and preserving both autoregulation and vascular reactivity. Neurosurgical patients anaesthetized with propofol were found to have lower ICP and higher CPP than those anaesthetized with isoflurane or sevoflurane. The well known pharmacodynamic advantages of intravenous anesthetics may give this group of drugs superior cerebral effects when compared with inhalation anesthetics.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Brain Tumor | Brain Neoplasm | ALIAS | 0.90 |
| Surgery | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Propofol-Dexmedetomidine group | Drug | — | UNRESOLVED |
| Sevoflurane group | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- PLACEBO_COMPARATOR
- label
- Propofol-Dexmedetomidine group
- description
- this group is planned to receive intravenous anaesthesia only
- interventionNames
- Drug: Propofol-Dexmedetomidine group
- type
- ACTIVE_COMPARATOR
- label
- Sevoflurane group
- description
- this group is planned to receive sevoflurane/fentanyl anaesthesia
- interventionNames
- Drug: Sevoflurane group
Primary outcomes (4)
- measure
- Arterio-Jugular oxygen content difference
- timeFrame
- immediately after cannulation (arterial and jugular), every 30 min during surgery and after complete closure of the scalp
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 20 Years
- Maximum age
- 60 Years
Show eligibility criteria text
Inclusion Criteria: * American Society of Anesthesiologists physical status III or IV. * Patients scheduled for elective brain tumor resection Exclusion Criteria: * Morbid obese patients. * Severe or uncompensated cardiovascular diseases. * Severe or uncompensated renal diseases. * Severe or uncompensated hepatic diseases. * Severe or uncompensated endocrinal diseases. * Pregnancy. * Postpartum or lactating females. * Allergy to one of the agents used. * Severely altered consciousness level. * Sitting position during surgery. * Prone position during surgery,
References
Publications (0)
Data not yet available