Clinical trial · Interventional
Skeletal Muscle Energy Metabolism in Undernourished Patients With Gastrointestinal Cancer
Study of Alterations in Skeletal Muscle Energy Metabolism in Undernourished Patients With Gastrointestinal Cancer
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Undernutrition associated with cancer, or cancer cachexia results from a deterioration of the energy balance that leads to a gradual mobilization of energy reserves in the body and to increasing deterioration of the nutritional status of patients. This will thus significantly reduce quality of life and survival of patients with a lower tolerance to cancer treatments. Despite undeniable progress in knowledge, many pathophysiological mechanisms remain few or not explored, which could explain that there is still no satisfactory therapeutic solution to halt the gradual deterioration of the nutritional status of patients. In this sense, apart from preclinical data obtained in animal models, there is currently no clinical study on the functioning of skeletal muscle energy metabolism in undernourished patients suffering of cancer.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Gastrointestinal Cancer | Malignant Digestive System Neoplasm | ALIAS | 0.90 |
| Undernutrition | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Samples | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- OTHER
- label
- Case group
- description
- the intervention, specific to the study, is to take samples on patients with advanced gastrointestinal cancer
- interventionNames
- Other: Samples
- type
- OTHER
- label
- Control group
- description
- the intervention, specific to the study, is to take samples on non-undernourished patients supported for adjuvant chemotherapy as part of colorectal cancer
- interventionNames
- Other: Samples
Primary outcomes (1)
- measure
- Measurement of muscle mitochondrial bioenergetics
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Case group selection criteria: Inclusion Criteria: * 18 years ≤ Age ≤ 80 years * Colorectal pancreatic cancer * Undernutrition related to cancer (weight loss \> 5% weight in one month or 10% in 6 months) * Indication to systemic chemotherapy * Indication to the development of an implantable port * Life expectancy ≥ 3 months * WHO General Status ≤ 2 * Patients affiliated to social security scheme * Informed consent signed by the patient Exclusion Criteria: * Pregnant or breastfeeding women * Unbalanced Diabetes * Systemic corticosteroid treatment * Any severe uncontrolled medical condition * Alopecia Control group selection criteria: Inclusion Criteria: * 18 years ≤ Age ≤ 80 years * Colorectal pancreatic cancer * Indication adjuvant chemotherapy * Indication to the development of an implantable port * Life expectancy ≥ 3 months * WHO General Status ≤ 2 * Patients affiliated to social security scheme * Informed consent signed by the patient Exclusion Criteria: * Pregnant or breastfeeding women * Undernutrition related cancer (weight loss \> 5% weight in one month or 10% in 6 months) * Unbalanced Diabetes * Systemic corticosteroid treatment * Any severe uncontrolled medical condition * Alopecia
References
Publications (1)
- RESULTDolly A, Lecomte T, Tabchouri N, Caulet M, Michot N, Anon B, Chautard R, Desvignes Y, Ouaissi M, Fromont-Hankard G, Dumas JF, Servais S. Pectoralis major muscle atrophy is associated with mitochondrial energy wasting in cachectic patients with gastrointestinal cancer. J Cachexia Sarcopenia Muscle. 2022 Jun;13(3):1837-1849. doi: 10.1002/jcsm.12984. Epub 2022 Mar 22. PMID 35316572