Clinical trial · Interventional
Clinical Trials of CT-guided Percutaneous Irreversible Electroporation（IRE）in the Treatment of Patients With Locally Advanced Tumors
Clinical Trials of CT-guided Percutaneous Irreversible Electroporation（IRE）in the Treatment of Patients With Locally Advanced Tumors：The Safety and Efficacy Assessment
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Irreversible electroporation (IRE) is an emerging nonthermal focal ablation technique that uses a series of short but intense electric pulses delivered by NanoKnife generator through paired electrodes into a targeted region of tissue, inducing the cells death by apoptosis through irreversibly disrupting cellular membrane integrity. This study aimed to investigate the safety and efficacy of CT-guided percutaneous irreversible electroporation（IRE） in the treatment of patients with locally advanced tumors in different anatomical position.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| CT-guided percutaneous irreversible electroporation | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Irreversible electroporation
- description
- In this group，eligible patients were selected to receive the CT-guided percutaneous irreversible electroporation ablation.
- interventionNames
- Procedure: CT-guided percutaneous irreversible electroporation
Primary outcomes (1)
- measure
- effective rate of IRE ablation
- timeFrame
- up to 12 months after the procedures
- description
- The procedure-related result will be assess by the size，blood supply，metabolism of the tumors. The changes of blood test are also considerable.
Secondary outcomes (2)
- measure
- 1-year survival rates
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: 1. Histologically confirmed locally advanced solid tumor. 2. Unresectable tumors or the patient refused surgical therapy. 3. Patients in good health conditions can receive general anesthesia. 4. Patients with good compliance can cooperate with doctors for related tests and the regular follow-up. Exclusion Criteria: 1. Targeted tissues that metallic wallstents or metallics were implanted. 2. With heart pacemaker or be allergic to contrast medium that can not have related imaging examinations. 3. With bleeding and psychiatric disorders. 4. Severe arrhythmia.
References
Publications (0)
Data not yet available