Clinical trial · Observational
Clinical and Laboratory Analysis of Familial Cancer
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Background: DNA makes up the instruction book for people s cells. Cancer is a disease caused by DNA changes that build up and affect cell function. Researchers want to learn more about what may cause cancer by testing the DNA of people with the disease and their family members. Objective: To find DNA changes that may be inherited and may cause or influence whether a person gets cancer. To study families with clusters of cancer to find out if there is a DNA mutation specific to certain cancers. Eligibility: People 18 years of age and older who: Participated in the familial genetic part of NIH study 09-C-0079, a previous study or had family members enrolled in this study Design: Participants may have been screened in the previous study. They will give permission for researchers to use their data and their tissue or blood samples collected in the study. Participants may give blood samples. At each stage of testing, participants will meet with a genetics health care provider. The provider will explain the tests and answer questions. If researchers find a DNA change that might increase the risk for cancer or other health issues, they will confirm this result in a testing lab. This will require a blood sample. Participants personal DNA data and health information will be put in a database for research purposes.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer | Malignant Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (2)
- label
- 1
- description
- Patients who were enrolled on protocol 09-C-0079, or family members of patients who were enrolled on protocol 09-C-0079
- label
- 2
- description
- Individuals found to harbor a germline APC promoter 1B variant not previously enrolled in Cohort l.
Primary outcomes (1)
- measure
- investigate relationship of familial genetic mutation to a particular cancer
- timeFrame
- 1 year
- description
- linkage analysis performed for familial clustering of malignant and pre-malignant disease in families
Secondary outcomes (1)
- measure
- To assess the phenotype of Gastric Adenocarcinoma and Proximal Polyposis of the Stomach (GAPPS)
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 10 Years
Show eligibility criteria text
* INCLUSION CRITERIA: * Participants must meet one of the following: * Have been previously enrolled on the familial genetic analysis arm of NIH study 09-C-0079; OR * Be family members of patients previously enrolled on the familial genetic analysis arm of 09-C-0079; OR * Have a documented pathogenic germline APC promotor 1B variant from a CLIA approved laboratory. * Participants must be 10 years of age or older EXCLUSION CRITERIA: Inability to provide informed consent.
References
Publications (0)
Data not yet available