Clinical trial · Interventional
Esmolol Versus Dexmedetomidine During Intracranial Procedures
Comparison of Esmolol and Dexmedetomidine on Sympathetic Control During Intracranial Procedures
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Patients undergoing intracranial procedures may experience severe hypertension and tachycardia due to intracranial hypertension and to increased release of adrenaline. Preventing perioperative sympathetic activity is of great importance. A common technique is using b-blockers like esmolol, which effectively block perioperative hemodynamic changes during intracranial surgery. A2 agonists, like Dexmedetomidine-Dex are now being used as a component of a balanced anesthesia during neurosurgical procedures. This study aimed to evaluate whether esmolol or dex attenuates perioperative changes in patients undergoing elective craniotomy with fast track neuroanesthesia.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Intracranial Aneurysm | — | UNRESOLVED | — |
| Intracranial Neoplasms | Intracranial Neoplasm | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Dexmedetomidine | Drug | — | UNRESOLVED |
| Esmolol | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Esmolol
- description
- Esmolol 500mcg/kg before induction in anesthesia following by 300mcg/Kg/min until extubation.
- interventionNames
- Drug: Esmolol
- type
- ACTIVE_COMPARATOR
- label
- Dexmedetomidine
- description
- Dexmedetomidine 1mcg/Kg following by 0.7mcg/Kg/h until end of surgery.
- interventionNames
- Drug: Dexmedetomidine
Primary outcomes (1)
- measure
- Systolic arterial pressure- mean arterial pressure (mmHg)
- timeFrame
- every 15minutes, starting from the induction in anesthesia through surgery completion and up to first 24 postoperative hours.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * Patients with ASA physical status 1-3 * Glasgow Coma Scale:13-15 * Hunt-Hess: 0-3 Exclusion Criteria: * Patients with ASA physical status \>3, * Body Mass Index (BMI) over 30, * indication for rapid sequence induction, * any contraindication for receiving b-blocker, * Glasgow Coma Scale (GCS) \<13, * history of drug abuse, * neurologic deficit or preoperatively foreseen delayed extubation, * preoperative heart rate\<45.
References
Publications (2)
- RESULTTanskanen PE, Kytta JV, Randell TT, Aantaa RE. Dexmedetomidine as an anaesthetic adjuvant in patients undergoing intracranial tumour surgery: a double-blind, randomized and placebo-controlled study. Br J Anaesth. 2006 Nov;97(5):658-65. doi: 10.1093/bja/ael220. Epub 2006 Aug 16. PMID 16914460
- RESULTGrillo P, Bruder N, Auquier P, Pellissier D, Gouin F. Esmolol blunts the cerebral blood flow velocity increase during emergence from anesthesia in neurosurgical patients. Anesth Analg. 2003 Apr;96(4):1145-1149. doi: 10.1213/01.ANE.0000055647.54957.77. PMID 12651674