Clinical trial · Observational
Pancreatic Exocrine Insufficiency in Acute Pancreatitis
Development of Pancreatic Exocrine Insufficiency After Moderately Severe or Severe Acute Pancreatitis
NCT02563080CI-TRIAL-00060336APPEIcompletedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Severe pancreatitis induces more damage in the pancreas and might therefore result reduced exocrine function leading to the insufficiency. The aim of this prospective study is to investigate development of pancreatic exocrine insufficiency in patients recovering from first attack of moderately severe or severe acute pancreatitis.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Acute Pancreatitis | — | UNRESOLVED | — |
| Exocrine Pancreatic Insufficiency | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
No intervention recorded.
Design
Arms and outcomes
Arms (1)
- label
- First attack of acute pancreatitis
- description
- 50 patients with first attack of moderately severe or severe acute pancreatitis treated in Helsinki University Hospital.
Primary outcomes (1)
- measure
- Development of pancreatic exocrine insufficiency after first attack of moderately severe or severe acute pancreatitis confirmed by fecal elastase-1 test.
- timeFrame
- One year after discharging from hospital
- description
- fecal elastase-1 \<200 ug/g
Secondary outcomes (2)
- measure
- Persistence of pancreatic exocrine insufficiency after first attack of moderately severe or severe acute pancreatitis
- timeFrame
- One year after discharging from hospital
- description
- fecal elastase-1 \<200 ug/g
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 90 Years
Show eligibility criteria text
Inclusion Criteria: * first episode of acute pancreatitis (diagnosis based on acute onset of characteristic symptoms and elevated plasma levels of amylase and/or typical findings on CT) * severity of acute pancreatitis classified as moderately severe or severe by revised Atlanta classification of acute pancreatitis 2012 Exclusion Criteria: * previous history of acute pancreatitis * chronic pancreatitis * known pancreatic exocrine insufficiency * previous pancreatic surgery
References
Publications (3)
- BACKGROUNDBanks PA, Bollen TL, Dervenis C, Gooszen HG, Johnson CD, Sarr MG, Tsiotos GG, Vege SS; Acute Pancreatitis Classification Working Group. Classification of acute pancreatitis--2012: revision of the Atlanta classification and definitions by international consensus. Gut. 2013 Jan;62(1):102-11. doi: 10.1136/gutjnl-2012-302779. Epub 2012 Oct 25. PMID 23100216
- BACKGROUNDBoreham B, Ammori BJ. A prospective evaluation of pancreatic exocrine function in patients with acute pancreatitis: correlation with extent of necrosis and pancreatic endocrine insufficiency. Pancreatology. 2003;3(4):303-8. doi: 10.1159/000071768. PMID 12890992
- DERIVEDLindstrom O, Lietzen E, Mentula P, Tolonen M, Siironen P, Udd M, Puolakkainen P, Kylanpaa L. Development of pancreatic exocrine insufficiency after first moderately severe or severe acute pancreatitis. Scand J Gastroenterol. 2025 Sep;60(9):921-927. doi: 10.1080/00365521.2025.2533337. Epub 2025 Jul 17. PMID 40673865