Clinical trial · Interventional
Complete Nerve-Sparing Radical Hysterectomy for Cervical Cancer
A Simplified Approach of Complete Nerve-sparing Type C1 Radical Hysterectomy for Cervical Cancer, a Phase II Study
NCT02562729CI-TRIAL-00024274completedPhase 2ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is to evaluate the feasibility of complete nerve-sparing type C1 radical hysterectomy in cervical cancer.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cervical Adenocarcinoma | Cervical Adenocarcinoma | CURATED_BROADER | 0.80 |
| Cervical Squamous Cell Carcinoma | Cervical Squamous Cell Carcinoma | CURATED_BROADER | 0.80 |
| Malignant Neoplasm of Cervix Stage IB1 | Malignant Cervical Neoplasm | CURATED_BROADER | 0.78 |
| Stage IIA1 Cervical Cancer | Malignant Cervical Neoplasm | CURATED_BROADER | 0.78 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Nerve-Sparing Radical Hysterectomy | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Nerve-Sparing Radical Hysterectomy (NSRH)
- description
- Type C1 Hysterectomy
- interventionNames
- Procedure: Nerve-Sparing Radical Hysterectomy
Primary outcomes (2)
- measure
- Proportion of patients with fully pelvic nerve plexus preserved
- timeFrame
- up to 30 days
- description
- Proportion of patients who had a postvoid residual urine volume (PVR) under 50ml at postoperative day 4
- measure
- Proportion of patients removing indwelling catheter
- timeFrame
- up to 30 days
Secondary outcomes (1)
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
- Maximum age
- 70 Years
Show eligibility criteria text
Inclusion Criteria: * Age \>=18 years to \<= 70 years. * Women with histologically confirmed, primary adenocarcinoma or squamous cell carcinoma of the uterine cervix. * Stage IIA1, or IB1 disease. * Karnofsky performance status \>70. * Patients who comply with follow-up. * With written informed consent. Exclusion Criteria: * Age\>70 * History of lower urinary tract damage or surgery. * With abnormal urodynamic study results. * Karnofsky performance status \<70. * Patients who have uncontrolled psychological disorders. * Unwilling to or unable to comply with protocol. * Prior treatment with pelvic radiotherapy
References
Publications (1)
- DERIVEDZhang Y, Shi T, Yin S, Ma S, Shi D, Guan J, Xiang L, Liu Y, Ren Y, Tan D, Zang R. An improved nerve-sparing radical hysterectomy technique for cervical cancer using the paravesico-vaginal space as a new surgical landmark. Oncotarget. 2017 Jul 5;8(52):90413-90420. doi: 10.18632/oncotarget.19011. eCollection 2017 Oct 27. PMID 29163840