Clinical trial · Interventional
Postoperative Analgesic Effect of Nefopam
NCT02561494CI-TRIAL-00024501completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Nefopam will be administered to the patients undergoing laparoscopic gastrectomy under the total intravenous anesthesia (TIVA). The investigators will evaluate whether the nefopam can decrease the total amount of remifentanil administered during the operation, which will reduce the acute opioid tolerance and following consumption of fentanyl during postoperative period.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Stomach Neoplasms | Gastric Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Nefopam | Drug | — | UNRESOLVED |
| Saline | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- PLACEBO_COMPARATOR
- label
- Control
- description
- Intravenous normal saline 2 ml is given slowly as a placebo before the anesthesia induction and after finishing anesthesia.
- interventionNames
- Drug: Saline
- type
- EXPERIMENTAL
- label
- Nefopam
- description
- Intravenous nefopam 20 mg is given slowly before the anesthesia induction and after finishing anesthesia.
- interventionNames
- Drug: Nefopam
Primary outcomes (1)
- measure
- Change of the administered fentanyl dose from postoperative 6 h to postoperative 5 day
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 20 Years
- Maximum age
- 70 Years
Show eligibility criteria text
Inclusion Criteria: * Early or advanced gastric cancer Exclusion Criteria: * Refusal * Use of preoperative analgesic drugs * Pregnancy * Recurred gastric cancer * Seizure * Cardiac disease * Monoamine oxidase inhibitor * Urologic disease * Previous intrabdominal surgery * Body mass index \> 30 or \< 16
References
Publications (0)
Data not yet available
No reference posted for this study.