Molecular Mechanisms of Senescence Predisposing to Cancer : Exploratory Analysis on Healthy Tissues (SkinAge).

Epidemiological data show that the incidence of carcinoma, the most common cancer, is strongly linked to the age. Non Melanoma Skin Carcinomas (NMSCs) (the most frequent cancers in the elderly population) derive from keratinocytes of the basal layer of the epidermis, from differentiated keratinocytes of the more superficial layers or from stem cells of hair follicles. Unlike NMSCs, soft-tissue sarcomas, including those deriving from dermal fibroblasts, are very rare (less than 1% of all cancers). Our overall purpose is to decipher the molecular pathways activated during the aging of these tissues that may explain why they have a so different propensity to undergo a malignant transformation. Given that senescent cells accumulate in the dermis and epidermis with age, we will constitute two groups : "young skin" that we arbitrarily limit to the range ≥ 18 and ≤ 40 and "aged skin" ≥ 55. Thus the main objective of our study is to search within 2 age groups (≥ 18 and ≤ 40 years and ≥ 55 years) the expression of senescence markers on healthy skin tissue.

Sex

All

Minimum age

18 Years

Inclusion Criteria:

* Patient with an operable sarcoma
* Requiring a surgical operation under general anesthesia at the Oscar Lambret Centre
* Age ≥ 18 ans, belonging to one of the two following age groups : \[ ≥ 18 and ≤ 40 years\] and \[ ≥ 55 years\]
* Patient having a social security scheme
* Patient having signed an informed consent form for the study

Exclusion Criteria:

* Patient aged under 18 or between 41 and 54
* Location of the tumor on the face, neck or neckline
* Patient with a skin tumor
* Tumor-induced cutaneous fistula making suspect a tumor invasion of the skin
* Patient with a chronic skin disease
* Collection in an area already treated by surgery, radiotherapy or brachytherapy
* Pregnant or breastfeeding women
* Patient under guardianship or tutorship