Clinical trial · Interventional
Dexmedetomidine or Dexmedetomidine Combined With Dexamethasone on Postoperative Nausea and Vomiting in Breast Cancer
Effects of Single Dose Dexmedetomidine or Dexmedetomidine Combined With Dexamethasone on Postoperative Nausea and Vomiting in Breast Cancer
NCT02550795CI-TRIAL-00046764completedN/AResults postedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Previous reports demonstrated that dexmedetomidine could reduce the incidence of postoperative nausea and vomiting (PONV). Dexamethason also had been commonly used for ajuvant drugs for preventing and reducing PONV. So investigator want to study about the effect of dexmedetomidine only or combined with dexamethasone for preventing PONV.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Postoperative Nausea and Vomiting | — | UNRESOLVED | — |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Control | Drug | — | UNRESOLVED |
| Dexmedetomidine | Drug | — | UNRESOLVED |
| Dexmedetomidine and dexamethasone | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- PLACEBO_COMPARATOR
- label
- Control
- description
- administration of 0.9% normal saline 10ml
- interventionNames
- Drug: Control
- type
- ACTIVE_COMPARATOR
- label
- Dexmedetomidine
- description
- administration of 0.5ug/kg of dexmedetomidine (5ml)
- interventionNames
- Drug: Dexmedetomidine
- type
- ACTIVE_COMPARATOR
- label
- Dexmedetomidine and dexamethasone
- description
- administration of 0.5 ug/kg of dexmedetomidine and dexamethasone 5mg (total 5ml)
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 20 Years
- Maximum age
- 65 Years
Show eligibility criteria text
Inclusion Criteria: * ASA Physical status I or II female scheduled for breast conserving surgery of modified radical mastectomy. Exclusion Criteria: * uncontrolled cardiovascular disease * history of chronic pain * smoker * previous history of steroid administraion * neoajuvant chemotherapy
References
Publications (0)
Data not yet available
No reference posted for this study.