Clinical trial · Observational
Identification of Prognostic Biomarkers for Progression of Invasive Squamous Cell Carcinoma
NCT02549638CI-TRIAL-00096506terminatedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): Lack of funding, slow accrual
Summary
Brief summary (as posted)
The study will utilize both retrospective and prospective data collection from patients that already had a bronchoscopy and lung resection or will have a bronchoscopy and lung resection for squamous cell carcinoma. The investigators plan to prospectively collect 5 bronchoscopic biopsies, 10ml blood and one tumor and adjacent normal samples from 200 qualified patients who meet the study criteria.
Conditions
Conditions (11)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer of Lung | Malignant Lung Neoplasm | CURATED_EXACT | 0.92 |
| Cancer of the Lung | Malignant Lung Neoplasm | CURATED_EXACT | 0.92 |
| Carcinoma, Squamous | Squamous Cell Carcinoma | ALIAS | 0.90 |
| Carcinoma, Squamous Cell | Squamous Cell Carcinoma | ONTOLOGY_EXACT | 0.98 |
| Lung Cancer | Malignant Lung Neoplasm | CURATED_EXACT | 0.92 |
| Lung Neoplasms | Lung Neoplasm | ONTOLOGY_EXACT | 0.98 |
| Neoplasms, Lung | Lung Neoplasm | ONTOLOGY_EXACT | 0.98 |
| Neoplasms, Pulmonary | Neoplasm | ONTOLOGY_EXACT | 0.85 |
| Pulmonary Cancer | — | UNRESOLVED | — |
| Pulmonary Neoplasms | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| DNA Extraction | Genetic | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Tissue Collection
- description
- We plan to prospectively collect 5 bronchoscopic biopsies, 3ml blood and one tumor and adjacent normal samples from 200 qualified patients who meet the study criteria. If a patient has already had a bronchoscopy and has samples available that were previously collected and stored for research at the Mayo Clinic we will use those samples.
- interventionNames
- Genetic: DNA Extraction
Primary outcomes (1)
- measure
- Number and types of recurrent genomic alterations evaluated by a custom targeted sequencing panel.
- timeFrame
- 2 years
- description
- The aim of this study is to identify and characterized recurrent genomic alteration found in invasive squamous cell carcinoma that are present in the precursor airway epithelial tissues but absent in normal tissues examined from samples taken during a lung procedure.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * known or suspected squamous cell carcinoma of the lung * able to provide consent * could have already had a bronchoscopy or surgical resection with tissue saved at the Mayo Clinic Rochester * will be undergoing a bronchoscopy and having a surgical resection at the Mayo Clinic Rochester Exclusion Criteria: * unable to provide consent * pregnant
References
Publications (0)
Data not yet available
No reference posted for this study.