Clinical trial · Observational
Follow-Up Study of People Treated for Scoliosis
Breast and Other Cancers Following X-Rays for Scoliosis
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Background: Scoliosis is a curving of the spine. It usually happens in girls when they are children and teens. Doctors often use x-rays to diagnose it. The x-rays give low radiation. This may increase the risk that those young women get cancer later in life. Researchers want to learn more about this risk. They will look data that has already been collected. Objectives: To study cancer risks of repeated low radiation from x-rays for scoliosis. Also, to study death risks related to certain scoliosis patient characteristics. These include causes, kinds of curvature, and kinds of treatment. Eligibility: Medical records of women from past scoliosis studies. Design: This U.S. Scoliosis Cohort includes more than 5,000 women who were diagnosed between 1912 and 1965. Data were collected on these women in the 1980s and 1990s. These came from medical records, radiology log books, and x-ray films. Researchers found out where participants were, including if they were dead. Some women were given a follow-up questionnaire. Researchers want to find out where participants are today. They want to identify new deaths of participants. They want to find out their causes of death. This data will be added to other databases.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| All Cause Mortality | — | UNRESOLVED | — |
| Breast and Other Cancer Incidence and Mortality | — | UNRESOLVED | — |
| Circulatory Disease Mortality | — | UNRESOLVED | — |
| Respiratory Disease Mortality | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (1)
- label
- Patientis
- description
- patients diagnosed with scoliosis and other spinal deformities
Primary outcomes (2)
- measure
- Cancer incidence
- timeFrame
- 1993
- description
- Incidence of breast and other cancers.
- measure
- Cancer and other disease mortality
- timeFrame
- 2015
- description
- Mortality from cancer and other causes.
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 50 Years
- Maximum age
- 95 Years
Show eligibility criteria text
* Data Analysis Only
References
Publications (3)
- BACKGROUNDDoody MM, Lonstein JE, Stovall M, Hacker DG, Luckyanov N, Land CE. Breast cancer mortality after diagnostic radiography: findings from the U.S. Scoliosis Cohort Study. Spine (Phila Pa 1976). 2000 Aug 15;25(16):2052-63. doi: 10.1097/00007632-200008150-00009. PMID 10954636
- BACKGROUNDRonckers CM, Doody MM, Lonstein JE, Stovall M, Land CE. Multiple diagnostic X-rays for spine deformities and risk of breast cancer. Cancer Epidemiol Biomarkers Prev. 2008 Mar;17(3):605-13. doi: 10.1158/1055-9965.EPI-07-2628. PMID 18349278
- BACKGROUNDRonckers CM, Land CE, Miller JS, Stovall M, Lonstein JE, Doody MM. Cancer mortality among women frequently exposed to radiographic examinations for spinal disorders. Radiat Res. 2010 Jul;174(1):83-90. doi: 10.1667/RR2022.1. PMID 20681802