Clinical trial · Interventional
Gingival Crevicular Fluid Vaspin and Omentin Levels in Type 2 Diabetic Patients With Chronic Periodontitis
Effects of Non-Surgical Periodontal Treatment on the Gingival Crevicular Fluid Levels of Vaspin and Omentin-1 in Type 2 Diabetic Patients With Chronic Periodontitis
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The aim of the present study were 1) to determine the role of these adipokines in the pathogenesis of periodontal disease, inflammation and tissue destruction comparing with gingival crevicular fluid (GCF) levels of TNF-α, which has a known pro-inflammatory effect in periodontal disease, 2) to investigate the effect of non-surgical periodontal treatment on GCF vaspin and omentin levels in type 2 diabetic (T2DM) patients with Chronic Periodontitis (CP).
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Chronic Periodontitis | — | UNRESOLVED | — |
| Diabetes Mellitus | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| gingival crevicular fluid | Other | — | UNRESOLVED |
| non-surgical periodontal treatment | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (4)
- type
- OTHER
- label
- diabetes mellitus group
- description
- gingival crevicular fluid was collected
- interventionNames
- Other: gingival crevicular fluid
- type
- OTHER
- label
- Control group
- description
- gingival crevicular fluid was collected
- interventionNames
- Other: gingival crevicular fluid
- type
- OTHER
- label
- diabetics with chronic periodontitis group
- description
- non-surgical periodontal treatment was completed and gingival crevicular fluid was collected
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 35 Years
- Maximum age
- 65 Years
Show eligibility criteria text
Inclusion Criteria: * Diabetic subjects should have T2DM and had no any known systemic diseases other than T2DM * Subjects who had HbA1c levels \< 8% and ≥ 6.5% (well and moderate control) * Chronic periodontitis patients had radiographic evidence of bone loss and attachment loss with a minimum of 6 teeth having pocket probing depth (PD) ≥ 5mm in at least 2 different quadrants * Control groups were designed as healthy if the full-mouth probing depth (PD) was ≤3mm and bleeding on probing (BOP) score \< %15 at examination and they had no radiographic evidence of alveolar bone loss. Exclusion Criteria: * Presence of other systemic disorders that could influence the course of periodontal disease; pregnancy, lactation, current and former use of tobacco; * Administration of non-steroidal and anti-inflammatory drugs or antibiotic therapies within the previous 6 months; * Need for antibiotic prophylaxis for dental treatment and having received non-surgical periodontal treatment within the past 6 months or surgical periodontal treatment within the past 12 months. * Subjects who had body mass index (BMI) \>24.9 kg /m2
References
Publications (0)
Data not yet available