Clinical trial · Interventional
A Comparison of the Effect of 1.5 Versus 3% NaCl on Brain Relaxation and Microcirculation
A Comparison of the Effect of 1.5% Versus 3% NaCl on Brain Relaxation and Microcirculation During the Supratentorial Brain Tumor Surgery, and Natremia and Osmolarity in Postoperative Period
NCT02537106CI-TRIAL-00040936completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Hyperosmotic solutions of 1.5% and 3% NaCl are equally effective for brain relaxation and microcirculation during brain surgery. The effect of 1.5% NaCl on postoperative natremia and natriuresis is less pronounced.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Brain Tumors | Brain Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| 1.5% NaCl | Procedure | — | UNRESOLVED |
| 3% NaCl | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- 1.5% NaCl
- description
- After standardized induction to general anesthesia group A patients will be given the infusion of hyperosmotic 1.5% NaCl 5 ml/kg/BW during 15 min.
- interventionNames
- Procedure: 1.5% NaCl
- type
- EXPERIMENTAL
- label
- 3% NaCl
- description
- After standardized induction to general anesthesia group B patients will be given the infusion of hyperosmotic 3% NaCl 5 ml/kg/BW during 15 min.
- interventionNames
- Procedure: 3% NaCl
Primary outcomes (1)
- measure
- Changes in brain microcirculation
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * peripheral supratentorial brain tumors or metastasis * indication for osmotherapy * ASA status I-III Exclusion Criteria: * reoperation * osmotherapy prior to surgery * preoperative natremia less than 135 mmol/l and more than 140 mmol/l * GCS less than 14 * obstructive hydrocephalus
References
Publications (0)
Data not yet available
No reference posted for this study.