Clinical trial · Interventional
Effect of Dexmedetomidine on Heart-rate Corrected QT(QTc) Interval Prolongation During Robotic-assisted Laparoscopic Radical Prostatectomy -Randomized Blind Clinical Trial-
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Sympathetic activity could be increased during robot-assisted laparoscopic radical prostatectomy, which is performed in a steep trendelenburg position under CO2 pneumoperitoneum. Stimulation of the sympathetic nervous system prolongs the QT interval and can increases the susceptibility to life threatening cardiac arrhythmias. Dexmedetomidine has sympatholytic effects and potential antiarrhythmic properties. Perioperative administration of dexmedetomidine is a potential preventive and treatment strategy for tachyarrhythmia. Thus the investigators decided to evaluate the effect of dexmedetomidine on heart-rate corrected QT interval during robot-assisted laparoscopic radical prostatectomy. Furthermore, the investigators evaluated the Tp-e, Tp-e/QT ratio and Tp-e/QTc ratio as well.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Prostate Cancer | Malignant Prostate Neoplasm | CURATED_EXACT | 0.92 |
| Robotic Surgery | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Dexmedetomidine | Drug | — | UNRESOLVED |
| Saline | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Dexmedetomidine
- interventionNames
- Drug: Dexmedetomidine
- type
- ACTIVE_COMPARATOR
- label
- Saline
- interventionNames
- Drug: Saline
Primary outcomes (1)
- measure
- Dexmedetomidine on heart-rate corrected QT(QTc) interval
- timeFrame
- From pre-induciton until 60 min after the end of pneumoperitoneum
- description
- QTc intervals (msec) are recorded from pre-induction until 60 min after the end of pneumoperitoneum
Eligibility
Eligibility (as posted)
- Sex
- Male
Show eligibility criteria text
Inclusion Criteria: 1. ASA class I-II 2. Otaining written informed consent from the patients who were undergoing robot- assisted laparoscopic radical prostatectomy Exclusion Criteria: 1. Emergency operation 2. Cardiac disease (unstable angina, congestive heart failure, valvular heart disease) 3. Ventricular conduction abnormality 4. Prior pacemaker insertion 5. Abnormal electrolyte values 6. Patients who take antiarrythmic agent 7. Hepatic or renal failure 8. Drug hyperactivity 9. Neurological or psychiatric illnesses
References
Publications (0)
Data not yet available