Clinical trial · Interventional
Cognition in Allogeneic Stem Cell Transplanted Patients and Sports
Effects of Physical Exercise on Cognitive Functions in Patients After Allogeneic Stem Cell Transplantation
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Studies suggest that patients with hematological malignancies undergoing allogeneic hematopoietic stem cell transplantation (HSCT) are at risk for cognitive decline and long-term cognitive dysfunction. To address this issue, a randomized controlled intervention trial on the effect of physical exercise on cognition is conducted. In addition, the impact on psychological and physical health outcomes is evaluated. Results may benefit patients who suffer from disease- or treatment-associated cognitive change.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Allogeneic Stem Cell Transplantation | — | UNRESOLVED | — |
| Exercise Intervention | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Control | Behavioral | — | UNRESOLVED |
| Exercise | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Exercise group
- description
- The exercise program will be developed through a pilot phase with 10 patients prior to the start of the main study.
- interventionNames
- Behavioral: Exercise
- type
- OTHER
- label
- Control group
- description
- A waitlist control group will get the intervention after 7 month of treatment as usual.
- interventionNames
- Behavioral: Control
Primary outcomes (1)
- measure
- Change in cognitive functioning as assessed by Change in total z-score
- timeFrame
- Baseline and 4 months
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 75 Years
Show eligibility criteria text
Patients: Inclusion Criteria: * hematological malignancy (AML, ALL, MDS, OMF, CML, MM, NHL, Hodgkin, AA) * 3 to 6 months after allogeneic HSCT * ≥ 18 years of age at time of transplantation * German as mother tongue * regular follow-up visits at the transplantation center during the first year after transplantation Exclusion Criteria: * \> 75 years of age at time of transplantation * relapse/progress * thrombocyte count ≤ 50 G/l * GvHD with lung involvement * compromised lung function (patients who need oxygen) * compromised cardiovascular function (\< 10-m walk) * florid infection * immobility * neurological disease * severe psychiatric disease * regular intake of psychoactive drugs or substance abuse * uncontrolled diabetes * high fracture risk * impaired vision and/or hearing Healthy controls (matched for age, gender, and education): Inclusion Criteria: * ≥ 18 years of age at time of enrolment * German as mother tongue * residence in the area of the transplantation center or family members/friends accompanying the patients to clinical follow-up visits Exclusion Criteria: * \> 75 years of age at time of enrolment * hematological malignancy * solid tumour disease * neurological disease * severe psychiatric disease * regular intake of psychoactive drugs or substance abuse * impaired vision and/or hearing
References
Publications (0)
Data not yet available