Clinical trial · Interventional
Omega-3 Supplementation for Smell Dysfunction
Effect of Omega-3 Supplementation in Patients With Smell Dysfunction Following Endoscopic Pituitary Tumor Resection
NCT02529332CI-TRIAL-00034468completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Omega-3 supplementation has been shown to have neuroprotective and potentially anti-inflammatory properties in both central and peripheral nerve injuries. The investigators are studying to see if omega-3 supplementation will affect olfactory (smell) function in patients with olfactory dysfunction following endoscopic removal of pituitary tumors.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Sellar/Parasellar Tumor | — | UNRESOLVED | — |
| Smell Dysfunction | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Omega-3 | Dietary Supplement | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Omega-3 Supplementation Group
- description
- Omega-3 supplementation
- interventionNames
- Dietary Supplement: Omega-3
- type
- NO_INTERVENTION
- label
- Control Group
Primary outcomes (2)
- measure
- Difference in Olfactory Function at baseline, based upon tumor type (i.e. functional vs. non-functional tumor)
- timeFrame
- Baseline (pre-tumor resection)
- description
- The University of Pennsylvania Smell Identification Test (UPSIT) will be used to determine baseline olfactory function prior to sellar/parasellar tumor resection for all subjects.The test consists of a total of 40 "scratch and sniff" strips which the individual must select the correct odor from four choices. The test is scored out of 40 items. The number of correct answers regarding the smells being experienced is the subject's score. The higher the score the better the sense of smell.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * sellar/parasellar tumor scheduled to undergo endoscopic transnasal transsphenoidal resection * 18 years of age or older * English speaking Exclusion Criteria: * Currently using blood thinning agents (aside from NSAIDs or cardioprotective ASA) * elevated AST, ALT, or alk phos \>10% outside of normal range, if randomized to omega-3 group * diabetes, if randomized to omega-3 group and not already on omega-3 prescribed by another provider * unable to provide informed consent due cognitive deficiencies
References
Publications (0)
Data not yet available
No reference posted for this study.