Clinical trial · Interventional
Association Between Heat Pain Detection Threshold and Area of Secondary Hyperalgesia
To Determine the Degree of Association Between Heat Pain Detection Threshold and Area of Secondary Hyperalgesia Following Brief Thermal Sensitization in Healthy Male Volunteers
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this prospective study is to investigate how close Heat Pain Detection Threshold is associated with the area of secondary hyperalgesia, elicited by the clinical pain model Brief Thermal Sensitization. Furthermore we wish to investigate how close the clinical pain model: Pain during 1 min. heating of the skin (45 degrees celsius), and the psychological tests, Pain Catastrophizing Scale and Hospital Anxiety and Depression Scale are associated with the area of secondary hyperalgesia, elicited by the clinical pain model Brief Thermal Sensitization.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Healthy | — | UNRESOLVED | — |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Brief thermal sensitization | Other | — | UNRESOLVED |
| Heat pain detection threshold | Other | — | UNRESOLVED |
| Pain during 1 min. thermal stimulation | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- OTHER
- label
- Clinical pain models
- description
- Brief thermal sensitization. Heat pain detection threshold. Pain during 1 min. thermal stimulation
- interventionNames
- Other: Brief thermal sensitization
- Other: Pain during 1 min. thermal stimulation
- Other: Heat pain detection threshold
Primary outcomes (1)
- measure
- Size of the Area of secondary hyperalgesia following Brief thermal sensitization, evaluated by cm2, and heat pain detection threshold registered by degrees celsius.
- timeFrame
- 7 days
- description
- How close is the Heat Pain Detection Threshold associated with the size of the area of secondary hyperalgesia induced by Brief thermal sensitization? Area of secondary hyperalgesia will be investigated on two separate study days separated with a minimum of 7 days. The association will be expressed in R2 and prediction intervals for the area of BTS given fixed values of HPDT.
Secondary outcomes (5)
Eligibility
Eligibility (as posted)
- Sex
- Male
- Minimum age
- 18 Years
- Maximum age
- 35 Years
Show eligibility criteria text
Inclusion Criteria: * Age \>18 years and \<35 years * Speak and understand Danish * Male gender * Study participants who have understood and signed the informed consent * No prescription medicine during the last 30 days. Exclusion Criteria: * Study participants that cannot cooperate to the test. * Study participants who have a weekly intake of \>21 units of alcohol, or a have consumed \>3 units of alcohol within 24 hours before experimental day. * Study participants with a substance abuse, assessed by the investigator. * Study participants, who have consumed analgesics less than 3 days before experimental day. * Study participants, who have consumed antihistamines less than 48 hours before experimental day. * Study participants, who have consumed antidepressant medication during the last 30 days before experimental day. * Study participants with chronic pain. * Study participants with neurological illnesses. * Study participants with psychiatric diagnoses. * Study participants with tattoos on the extremities. * Study participants with eczema, wounds or sunburns on the sites of stimulation. * Study participants with a Body Mass Index of \>30 kg/m2 or \<18 kg/m2
References
Publications (2)
- DERIVEDHansen MS, Asghar MS, Wetterslev J, Pipper CB, Johan Martensson J, Becerra L, Christensen A, Nybing JD, Havsteen I, Boesen M, Dahl JB. Is the Volume of the Caudate Nuclei Associated With Area of Secondary Hyperalgesia? - Protocol for a 3-Tesla MRI Study of Healthy Volunteers. JMIR Res Protoc. 2016 Jun 17;5(2):e117. doi: 10.2196/resprot.5680. PMID 27317630
- DERIVEDHansen MS, Wetterslev J, Pipper CB, Asghar MS, Dahl JB. Is heat pain detection threshold associated with the area of secondary hyperalgesia following brief thermal sensitization? A study of healthy volunteers - design and detailed plan of analysis. BMC Anesthesiol. 2016 May 31;16(1):28. doi: 10.1186/s12871-016-0193-2. PMID 27246322