Clinical trial · Interventional
The Influence of Resection Margin on the Recurrence of Early-stage Hepatocellular Carcinoma
The Influence of Resection Margin on the Recurrence of Early-stage Hepatocellular Carcinoma After Hepatectomy: a Randomized Controlled Trial
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Before the surgery, the investigators predict the risk of microvascular invasion (MVI) presence for the early-stage hepatocellular carcinoma according to the nomogram the investigators have created. Patients with a high risk of microvascular invasion were randomly chose to give the treatment of a wide resection margin, which establish an individualized anti-recurrence program based on the high-grade evidence-based medicine.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Hepatocellular Carcinoma | Hepatocellular Carcinoma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Narrow resection margin <1cm | Procedure | — | UNRESOLVED |
| Wide resection margin >1cm | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Wide resection margin >1cm
- description
- Surgical removal of lesions choosing the method of wide resection margin \>1cm
- interventionNames
- Procedure: Wide resection margin >1cm
- type
- ACTIVE_COMPARATOR
- label
- Narrow resection margin <1cm
- description
- Surgical removal of lesions choosing the method of narrow resection margin \<1cm
- interventionNames
- Procedure: Narrow resection margin <1cm
Primary outcomes (1)
- measure
- Overall survival rates of each group
- timeFrame
- 3 years
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 70 Years
Show eligibility criteria text
Inclusion Criteria: * Male or female patients \> 18 years and \<=70 years of age. * Diagnosed with HCC according to the criteria of American Association for the Study of Liver Diseases (AASLD). * Fulfill the Milan criteria. * High-risk of microvascular invasion (MVI). * Nomogram score \>200. * Performance status score is 0-1 before the surgery. * Without or mild liver cirrhosis and the liver function is Child A class. * Without any other treatments such as TACE、PEI、PRFA before the surgery. Exclusion Criteria: * Patients with macro tumor thrombus or extrahepatic metastasis. * Patients with apparent cardiac, pulmonary, cerebral and renal dysfunction. * Subjects accepting other trial drugs or participating in other clinical trials. * Patients refuse to join our trial. * Female with pregnancy or during the lactation period.
References
Publications (0)
Data not yet available